Blood group AB is associated with severe forms of dengue virus infection
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Several viral and host factors are believed to contribute to the development of severe forms of dengue such as dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) following a dengue virus (DENV) infection. The pathogenesis of DHF/DSS is not fully understood, however, host factors like ABO blood groups have been shown to contribute to the severity of DENV infection. The present study investigated the association of blood groups with severity of DENV infection in the northern region of Sri Lanka. The blood-groups of 405 patients positive for DENV NS1 antigen and anti-DENV IgM/IgG were determined using the standard haemagglutination assay recommended by the national blood bank/s. The occurrence of severe dengue in patients with certain blood groups was significantly different (p < 0.001) to those with other blood groups. Patients with AB blood group had more than 2.5 times higher risk of developing DHF than those with other blood groups. On the other hand, patients with blood group O were significantly under represented for DHF relative to the proportion of this blood group in the general population. Thus dengue patients with blood group O appear to have a low risk of developing DHF than those with other blood groups.
KeywordsDengue fever Dengue haemorrhagic fever ABO blood groups
We thank the financial support from the Ministry of Higher Education of Sri Lanka (HETC JEN/O-MED/N7) and the Australian High Commission Direct Aid Programme (for ELISA kits).
- 4.Fry AE, Griffiths MJ, Auburn S, Diakite M, Forton JT, Green A, Richardson A, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Rockett KA, Kwiatkowski DP. Common variation in the ABO glycosyl transferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet. 2008;17:567–76.CrossRefPubMedGoogle Scholar
- 12.Rowe JA, Handel IG, Thera MA, Deans AM, Lyke KE, Koné A, Diallo DA, Raza A, Kai O, Marsh K, Plowe CV, Doumbo OK, Moulds JM. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced resetting. Proc Natl Acad Sci. 2007;104:17471–6.CrossRefPubMedPubMedCentralGoogle Scholar
- 13.Zar JH. Biostatistical analysis. 4th ed. Upper Saddle River: Prentice-Hall International; 1999.Google Scholar