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Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection

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A Correction to this article was published on 08 December 2017

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Abstract

TP53 and phosphate and tension homolog (PTEN) are two tumor suppressor genes that regulate cell proliferation, migration, and death. P53 and PTEN deficiency has been associated with hepatic fibrosis, a prominent pathological feature associated with chronic hepatitis B (CHB). The present study is aimed to assess the association of PTEN 32-bp Ins/Del (rs34421660) and TP53 16-bp Ins/Del polymorphisms with CHB infection susceptibility. A total of 411 subjects were recruited in this case–control study of 213 patients with CHB infection and 198 healthy individuals as controls. PTEN and TP53 deletions were detected by polymerase chain reaction method. We found no significant association between PTEN 32-bp Ins/Del polymorphism and the risk for CHB using either of codominant (Ins/Del vs. Ins/Ins: P = 0.427; Del/Del vs. Ins/Ins: P = 0.235), dominant (Ins/Del + Del/Del vs. Ins/Ins P = 0.343) or recessive genetic model (Del/Del vs. Ins/Ins + Ins/Del: P = 0.516). At allelic level although the PTEN Del variant allele was more common in CHB patients compared to controls (55 vs. 51), but the difference did not reach the statistical significant range (OR 0.87, P = 0.327). Similarly, no association was observed between TP53 16-bp Ins/Del and the risk for CHB infection at both genotype and allele levels (P > 0.05). In summary, our study demonstrated that the PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms did not affect the risk of CHB infection in the Iranian population.

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Change history

  • 08 December 2017

    In the original publication, the corresponding author’s city name was incorrectly published in the affiliation section. The correct information is given below. 5Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran.

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Acknowledgements

The authors are grateful for the cooperation of all individuals who voluntarily took part in the present study. We thank the Research Deputy of Zahedan University of Medical Sciences, Iran for funding this research.

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Authors and Affiliations

  1. Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran

    Ebrahim Eskandari

  2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran

    Ebrahim Eskandari

  3. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of Iran

    Tayebeh Dahmardeh

  4. Biology Department, School of Science, Zabol University, Zabol, Islamic Republic of Iran

    Fatemeh Dahmardeh

  5. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zabol, Islamic Republic of Iran

    Elham Pahlevani & Malihe Metanat

Authors
  1. Ebrahim Eskandari
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  2. Tayebeh Dahmardeh
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  3. Fatemeh Dahmardeh
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  4. Elham Pahlevani
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Corresponding author

Correspondence to Elham Pahlevani.

Additional information

A correction to this article is available online at https://doi.org/10.1007/s13337-017-0417-1.

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Eskandari, E., Dahmardeh, T., Dahmardeh, F. et al. Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection. VirusDis. 28, 289–294 (2017). https://doi.org/10.1007/s13337-017-0391-7

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  • DOI: https://doi.org/10.1007/s13337-017-0391-7

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