Photonic Sensors

, Volume 9, Issue 4, pp 309–316 | Cite as

A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes

  • Yinquan YuanEmail author
  • Na Yuan
  • Dejing Gong
  • Minghong YangEmail author
Open Access


An improved glucose sensitive membrane (GSM) is prepared by immobilizing glucose oxidase (GOD) onto a mixture of silica mesocellular foams (SiMCFs) and SiO2 nanoparticles (SiNPs) and then trapping it in a polyvinyl alcohol (PVA) gel. The membrane is coated onto a gold-glass sheet to create a surface plasmon resonance (SPR) sensor. A series of experiments are conducted to determine the optimized parameters of the proposed GSM. For a GSM with a component ratio of SiMCFs: SiNPs = 7: 3 (mass rate), the resonance angle of the sensor decreases from 68.57° to 63.36°, and the average sensitivity is 0.026°/(mg/dL) in a glucose concentration range of 0 mg/dL‒200 mg/dL. For a GSM with a component ratio of SiMCFs: SiNPs = 5: 5 (mass rate), the resonance angle of the sensor decreases from 67.93° to 63.50°, and the sensitivity is 0.028°/(mg/dL) in a glucose concentration range of 0 mg/dL‒160 mg/dL. These data suggest that the sensor proposed in this study is more sensitive and has a broader measurement range compared with those reported in the literature to date.


Surface plasmon resonance sensor glucose sensitive membrane immobilized enzyme silica mesocellular foams 



This work was funded by the National Natural Science Foundation of China (Grant No. 61575151).


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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.National Engineering Laboratory for Fiber Optic Sensing TechnologyWuhan University of TechnologyWuhanChina

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