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Pharmacokinetic interaction of enrofloxacin/trimethoprim combination following single-dose intraperitoneal and oral administration in rats

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Abstract

The pharmacokinetic interaction of enrofloxacin and trimethoprim was evaluated after single-dose intraperitoneal or oral co-administration in rats. Plasma concentrations of the two drugs were determined by high-performance liquid chromatography. Following intraperitoneal combination, a significant (P < 0.05) increase in mean values of plasma half-life (t 1/2) and maximum plasma concentration (C max) was observed for enrofloxacin and trimethoprim, respectively. There was a significant (P < 0.05) increase in mean values of area under the plasma drug concentration versus time from time zero to infinity (AUC0–∞) and C max between combined oral doses (10, 30 and 100 mg/kg) of both antibacterial drugs. Also, after oral conjugation a significant difference in mean values of MRT0–∞ was observed between lower (10 mg/kg) and higher (100 mg/kg) doses of both drugs. A significant increase in pharmacokinetic parameters of both drugs in combined intraperitoneal and oral doses indicated pharmacokinetic interaction of enrofloxacin and trimethoprim. Further study is recommended in other species of animals.

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Acknowledgments

This research was supported in part by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2011-0021670), in part by the Next-Generation BioGreen 21 Program (No. PJ009007).

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The authors have no conflict of interest.

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Authors and Affiliations

  1. Veterinary Clinical Pharmacology Laboratory, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, South Korea

    Myung-Jin Choi, Sileshi Belew Yohannes, Seung-Jin Lee, Dereje Damte & Seung-Chun Park

  2. Division of Bioscience and Bioinformatics, Science Campus, Myongji University, San 38-2 Namdong, Cheoin-Gu, Yongin, Gyeonggi, 449-728, Republic of Korea

    Joo-Won Suh

  3. Veterinary Toxicology Laboratory, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, Republic of Korea

    Jong-Choon Kim

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  1. Myung-Jin Choi
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  2. Sileshi Belew Yohannes
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  3. Seung-Jin Lee
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  4. Dereje Damte
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  5. Jong-Choon Kim
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  7. Seung-Chun Park
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Corresponding author

Correspondence to Seung-Chun Park.

Additional information

M.-J. Choi and B. Yohannes contributed equally.

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Choi, MJ., Yohannes, S.B., Lee, SJ. et al. Pharmacokinetic interaction of enrofloxacin/trimethoprim combination following single-dose intraperitoneal and oral administration in rats. Eur J Drug Metab Pharmacokinet 39, 11–16 (2014). https://doi.org/10.1007/s13318-013-0142-0

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  • DOI: https://doi.org/10.1007/s13318-013-0142-0

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