Neurotherapeutics

, Volume 14, Issue 1, pp 4–10 | Cite as

Magnetoencephalography and New Imaging Modalities in Epilepsy

  • Jessica Falco-Walter
  • Christian Owen
  • Mishu Sharma
  • Christopher Reggi
  • Mandy Yu
  • Travis R. Stoub
  • Michael A. Stein
Review

Abstract

The success of epilepsy surgery is highly dependent on correctly identifying the entire epileptogenic region. Current state-of-the-art for localizing the extent of surgically amenable areas involves combining high resolution three-dimensional magnetic resonance imaging (MRI) with electroencephalography (EEG) and magnetoencephalography (MEG) source modeling of interictal epileptiform activity. Coupling these techniques with newer quantitative structural MRI techniques, such as cortical thickness measurements, however, may improve the extent to which the abnormal epileptogenic region can be visualized. In this review we assess the utility of EEG, MEG and quantitative structural MRI methods for the evaluation of patients with epilepsy and introduce a novel method for the co-localization of a structural MRI measurement to MEG and EEG source modeling. When combined, these techniques may better identify the extent of abnormal structural and functional areas in patients with medically intractable epilepsy.

Keywords

MEG EEG MRI Epilepsy Imaging Focal cortical dysplasia 

Supplementary material

13311_2016_506_MOESM1_ESM.pdf (1.2 mb)
ESM 1(PDF 1224 kb)

References

  1. 1.
    Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia 2010;51:883–890.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Sperling MR, Feldman H, Kinman J, Liporace JD, O'Connor MJ. Seizure control and mortality in epilepsy. Ann Neurology 1999;46:45-50.CrossRefGoogle Scholar
  3. 3.
    Kwan P, Arzimanoqlou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshe SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2000;51:1069-1077.CrossRefGoogle Scholar
  4. 4.
    Wiebe S, Blume WT, Girvin JP, Eliasziw M. A randomized controlled trial of surgery for temporal lobe epilepsy. New England Journal of Medicine 2001;345: 311-318.CrossRefPubMedGoogle Scholar
  5. 5.
    Engel J Jr, McDermott MP, Wiebe S, Langfitt JT, Stern JM, Dewar S, Sperling M, Gardiner I, Erba G, Fried I, Jacobs M, Vinters HV, Mintzer S, Kieburtz K. (2012) Early surgical therapy for drug-resistant temporal lobe epilepsy. JAMA 307:922–930CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Sisodiya SM. Surgery for malformations of cortical development causing epilepsy. Brain 2000;123:1075-1091.CrossRefPubMedGoogle Scholar
  7. 7.
    Fauser S, Essang C, Altenmuller D, Staack AM, Steinhoff J, Strobl K, Bast T, Schubert-Bast S, Stephani U, Wiegand G, Prinz M, Brandt A, Zentner J, Schulze-Bonhage A. Long-term seizure outcome in 211 patients with focal cortical dysplasia. Epilepsia 2015;56:66-76.CrossRefPubMedGoogle Scholar
  8. 8.
    Téllez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain 2005;128:1188-1198.CrossRefPubMedGoogle Scholar
  9. 9.
    Perry M, Duchowny M. Surgical versus medical treatment for refractory epilepsy: Outcomes beyond seizure control. Epilepsia 2013;54:2060-2070.CrossRefPubMedGoogle Scholar
  10. 10.
    Columbo N, Tassi L, Calli C, Citterio A, Russo GL, Scialfa G, Spreafico R. Focal cortical dysplasia: MR imaging, histopathologic, and clinical correlations in surgically treated patients with epilepsy. Am J Neuroradiol 2003;24:724-733.Google Scholar
  11. 11.
    Bernasconi A, Antel SB, Collins DL, Bernasconi N, Olivier A, Dubeau F, Pike GB, Andermann F, Arnold D. Texture analysis and morphological processing of magnetic resonance imaging assist detection of focal cortical dysplasia in extra-temporal partial epilepsy, Annals of Neurology 2001;49(6):770-775.CrossRefPubMedGoogle Scholar
  12. 12.
    Perry MS, Dunvoyer C, Dean P, Bhatia S, Ragheb J, Miller I, Resnick T, Jayakar P, Duchowny M. Predictors of seizure freedom after incomplete resection in children. Neurology 2010;75:1448-1453.CrossRefPubMedGoogle Scholar
  13. 13.
    Colombo N, Salamon N, Raybaud C, Ozkara C, Barkovich J. Imaging of malformations of cortical development. Epileptic Disorders 2009;11:194-205.PubMedGoogle Scholar
  14. 14.
    Harvey AS, Cross JH, Shinnar S, Mathern GW. Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia 2008;49:146–155.CrossRefPubMedGoogle Scholar
  15. 15.
    Lerner JT1, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J Jr, Fried I, Cepeda C, Andre VM, Levine MS,Miyata H, Yong WH, Vinters HV, Mathern GW. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia. 2009;50:1310-35.Google Scholar
  16. 16.
    Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD. Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain 1995;118:629–660.CrossRefPubMedGoogle Scholar
  17. 17.
    Columbo N, Salamon N, Raybaud C, Ozkara C, Barkovich AJ. Imaging of malformations of cortical development. Epileptic Disord 2009;11:194-205.Google Scholar
  18. 18.
    Besson P, Andermann F, Dubeau F, Bernasconi A. Small focal cortical dysplasia lesions are located at the bottom of a deep sulcus. Brain 2008;131: 3246-3255.CrossRefPubMedGoogle Scholar
  19. 19.
    Thesen T, Quinn BT, Carlson C, Devinsky O, DuBois J, McDonald CR, French J, Leventer R, Felsovalyi O, Halgren E, Kuzniecky R. Detection of epileptogenic cortical malformations with surface-based MRI morphometry. PLoS ONE 2011;6:e16430.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y, Andermann E, et al. Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann Neurol 1991;30:741–9.CrossRefPubMedGoogle Scholar
  21. 21.
    Besson P, Bernasconi N, Colliot O, Evans A, Bernasconi A. Surface-based texture and morphological analysis detects subtle cortical dysplasia. Med Image Comput Comput Assist Interv 2008;11:645–652.PubMedGoogle Scholar
  22. 22.
    Bonilha L, Montenegro MA, Rorden C, Castellano G, Guerreiro MM, Cendes F, Lui LM. Voxel-based morphometry reveals excess gray matter concentration in patients with focal cortical dysplasia. Epilepsia 2006;47:908–915.CrossRefPubMedGoogle Scholar
  23. 23.
    Colliot O, Mansi T, Bernasconi N, Naessens V, Klironomos D, Bernasconi A. Segmentation of focal cortical dysplasia lesions on MRI using level set evolution. Neuroimage 2006;32:1621-1630.CrossRefPubMedGoogle Scholar
  24. 24.
    Kassubek J, Huppertz HJ, Spreer J, Schulze-Bonhage A. Detection and localization of focal cortical dysplasia by voxel-based 3-D MRI analysis. Epilepsia 2002;43:596-602.CrossRefPubMedGoogle Scholar
  25. 25.
    Hong SJ, Kim H, Schrader D, Bernasconi N, Bernhardt BC, Bernasconi A. Automated detection of cortical dysplasia type II in MRI-negative epilepsy. Neurology 2014;83:48-55.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Ronan L, Scanlon C, Murphy K, Maguire S, Delanty N, Doherty C, Fitzsimons M. Cortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical development. Epilepsia 2011;52:28-34.CrossRefPubMedGoogle Scholar
  27. 27.
    Wilke M, Kassubek J, Ziyeh S, Schulze-Bonhage A, Huppertz HJ. Automated detection of gray matter malformations using optimized voxel-based morphometry: a systematic approach. NeuroImage 2003; 20:330–343.CrossRefPubMedGoogle Scholar
  28. 28.
    Zhang J, Liu W, Chen H, Xia H, Zhou Z, Mei S, Liu Q, Li Y. Multimodal neuroimaging in presurgical evaluation of drug-resistant epilepsy. Neuroimage Clinical 2013;4:35-44.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Mehta S, Grabowski TJ, Damasio H. Evaluation of voxel-based morphometry for focal lesion detection in individuals. Neuroimage 2003;20:1438-1454.CrossRefPubMedGoogle Scholar
  30. 30.
    Cardinale F, Chinnici G, Bramerio M, Mai R, Sarori I, Cossu M, Lo Russo G, Castana L, Columbo N, Caborni C, De Moni E, Ferrigno G. Validation of Freesurfer-estimated brain cortical thickness: comparison with histologic measurements. Neuroinformatics 2014;12:535-542.CrossRefPubMedGoogle Scholar
  31. 31.
    Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology 2002;58:695-701.CrossRefPubMedGoogle Scholar
  32. 32.
    Kuperberg, G.R., Broome, M.R., McGuire, P.K., David, A.S., Eddy, M., Ozawa, F., Goff, D., West, W.C., Williams, S.C., van der Kouwe, A.J., Salat, D.H., Dale, A.M., Fischl, B. Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 2003;60:878-888.CrossRefPubMedGoogle Scholar
  33. 33.
    Salat, D.H., Buckner, R.L., Snyder, A.Z., Greve, D.N., Desikan, R.S., Busa, E., Morris, J.C., Dale, A.M., Fischl, B., 2004. Thinning of the cerebral cortex in aging. Cereb Cortex 2004;14:721-730.CrossRefPubMedGoogle Scholar
  34. 34.
    Ebersole JS. Defining epileptogenic foci: past, present, future. J Clin Neurophysiol 1997;14:470-483.CrossRefPubMedGoogle Scholar
  35. 35.
    Ebersole JS, Squires KC, Eliashiv SD, Smith JR. Application of magnetic source imaging in evaluation of candidates for epilepsy surgery. Neuroimaging Clin N Am 1995;5:267-288.PubMedGoogle Scholar
  36. 36.
    Bast T, Oezkan O, Rona S, Stippich C, Seitz A, Rupp A, FauserS, Zentner J, Rating D, Scherg M. EEG and MEG source analysis of single and averaged interictal spikes reveals intrinsic epileptogenicity in focal cortical dysplasia. Epilepsia 2004;45:621-631.CrossRefPubMedGoogle Scholar
  37. 37.
    Wilenius J, Medvedovsky M, Metsahonkala L, Makela JP, Paetau A, Valanne L, Paetau R. Interictal MEG reveals focal cortical dysplasias: Special focus on patients with no visible MRI lesions. Epilepsy Research 2013;105:337-348.CrossRefPubMedGoogle Scholar
  38. 38.
    Wu XT, Rampp S, Buchfelder M, Kuwert T, Blumcke I, Dorfler A, Zhou D, Stefan H. Interictal magnetoencephalography used in magnetic resonance imaging-negative patients with epilepsy. Acta Neurologica Scandinavica 2013;127:274-280.CrossRefPubMedGoogle Scholar
  39. 39.
    Chandra SP, Bal CS, Jain S, Joshua SP, Gaikwad S, Garg A, Ansari A, Nehra A, Sarkar C, Tripathi M. Intraoperative coregistration of magnetic resonance imaging, positron emission tomography, and electrocorticographic data for neocortical lesional epilepsies ma improve the localization of the epileptogenic focus: a pilot study. World Neurosurg 2014;82:110-117.CrossRefPubMedGoogle Scholar
  40. 40.
    Fernandez S, Donaire A, Seres E, Setoain X, Falcon C, Bargallo N, Sanmarti F, Maestro I, Rumia J, Boget T, Aparicio J, Carreno M. PET/MRI and PET/MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy. Epilepsy Res 2015;111:1-9.CrossRefPubMedGoogle Scholar
  41. 41.
    Storti SF, Formaggio E, Franchini E, Bongiovanni LG, Cerini R, Fiaschi A, Michel CM, Manganotti P. A multimodal imaging approach to the evaluation of post-traumatic epilepsy. MAGMA 2012;25:345-360.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Colliot O, Bernasconi N, Khalili N, Antel SB, Naessens V, Bernasconi A. Individual voxel-based analysis of gray matter in focal cortical dysplasia. Neuroimage 2006;29:162–171.CrossRefPubMedGoogle Scholar
  43. 43.
    Kim H, Bernasconi N, Bernhardt N, Colliot O, Bernasconi A. Basal temporal sulcal morphology in healthy controls and patients with temporal lobe epilepsy. Neurology 2008:2159-2165.Google Scholar
  44. 44.
    Bruggemann JM, Wilke M, Som SS, Bye AME, Bleasel A, Lawson JA. Voxel-based morphometry in the detection of dysplasia and neoplasia in childhood epilepsy: combined grey/white matter analysis augments detection. Epilepsy Res 2007;77(2–3):93–101.Google Scholar

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2017

Authors and Affiliations

  • Jessica Falco-Walter
    • 1
  • Christian Owen
    • 2
  • Mishu Sharma
    • 3
  • Christopher Reggi
    • 2
  • Mandy Yu
    • 2
  • Travis R. Stoub
    • 2
  • Michael A. Stein
    • 4
  1. 1.Department of Neurology and Neurological SciencesStanford University School of MedicineStanfordUSA
  2. 2.Department of Neurological SciencesRush University Medical CenterChicagoUSA
  3. 3.Rush Medical CollegeChicagoUSA
  4. 4.Department of NeurologyBarrow Neurological InstitutePhoenixUSA

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