, Volume 14, Issue 1, pp 176–181

Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Treatment of Drug-Resistant Epilepsy

Current Perspectives

DOI: 10.1007/s13311-016-0498-3

Cite this article as:
Kang, J.Y. & Sperling, M.R. Neurotherapeutics (2017) 14: 176. doi:10.1007/s13311-016-0498-3


Surgery is the most effective treatment for drug-resistant epilepsy. Long-term studies demonstrate that about 60% to 80% of patients become seizure-free after anterior temporal lobectomy and a majority of patients (about 95%) report significant seizure reduction after surgery. In the last few years, there has been significant advances in minimally invasive surgical techniques to treat drug-resistant epilepsy. These minimally invasive procedures have significant advantages over open surgery in that they produce less immediate discomfort and disability, while allowing for greater preservation of functional tissue. Laser interstitial thermal therapy (LiTT) is an example of such a procedure. Recent advances in imaging, surgical navigation, and real-time thermal monitoring have made LiTT safer and easier to implement, offering an effective and powerful neurosurgical tool for drug-resistant epilepsy. This article will review the technical considerations, uses, and potential future directions for LiTT in drug-resistant epilepsy.

Key Words

Laser interstitial thermal therapy drug-resistant epilepsy epilepsy temporal lobe epilepsy mesial temporal sclerosis temporal lobectomy. 

Supplementary material

13311_2016_498_MOESM1_ESM.pdf (1.2 mb)
ESM 1(PDF 1224 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2016

Authors and Affiliations

  1. 1.Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Thomas Jefferson University HospitalPhiladelphiaUSA

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