, Volume 14, Issue 1, pp 107–118

Electrical Impedance Myography and Its Applications in Neuromuscular Disorders


DOI: 10.1007/s13311-016-0491-x

Cite this article as:
Sanchez, B. & Rutkove, S.B. Neurotherapeutics (2017) 14: 107. doi:10.1007/s13311-016-0491-x


Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among its advantages, the technique can be used noninvasively across a variety of disorders and requires limited subject cooperation and evaluator training to obtain accurate and repeatable data. Studies in both animals and human subjects support its potential utility as a primary diagnostic tool, as well as a biomarker for clinical trial or individual patient use. This review begins by providing an overview of the current state and technological advances in electrical impedance myography and its specific application to the study of muscle. We then provide a summary of the clinical and preclinical applications of EIM for neuromuscular conditions, and conclude with an evaluation of ongoing research efforts and future developments.

Key Words

Electrical impedance muscle myopathy neurogenic disease disuse injury 

Supplementary material

13311_2016_491_MOESM1_ESM.pdf (1.2 mb)
ESM 1(PDF 1225 kb)

Funding information

Funder NameGrant NumberFunding Note
National Institute of Neurological Disorders and Stroke
  • K24NS060951
National Institute of Neurological Disorders and Stroke
  • R01NS055099

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2016

Authors and Affiliations

  1. 1.Department of Neurology, Division of Neuromuscular Disease, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA

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