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Development of the ‘PREDICT’ score through a systematic review and meta-analysis of the predictive parameters for locoregional recurrence after total mesorectal excision

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Abstract

Background

Despite robust management techniques, locoregional recurrence rates of rectal cancer are still significant. Although offering intensive follow-up has been shown to be beneficial in the early detection, it can be resource consuming. Having a robust knowledge of risk factors of locoregional recurrence will help in identification of patients who actually need intensive follow-up programs. This review aimed to identify the factors that can predict locoregional recurrence after Total mesorectal excision (TME).

Methods

We systematically reviewed PubMed, Scopus and Cochrane for relevant articles with no date restrictions while language was restricted to English. We only included articles that had either provided Hazards ratio (HR)/odds ratio (OR) or provided enough data that allowed calculation of HR/OR specifically for rectal cancer. Articles were deemed eligible if they included patients undergoing (TME).

Results

Seventeen studies (18,605 patients) published between 2002 and 2019 were included. A total of 699 patients developed locoregional recurrence at a median time of 25.2 months after surgery. There were eight significant predictors evaluated by more than one study; T3–T4 stage, circumferential resection margin, lymphovascular invasion, mucinous histology, N1–N2 stage, positive distal resection margin, Tumor < 5 cm from anal verge, and lack of neoadjuvant radiotherapy. A scoring system was developed based on the weight and pooled OR/HR of each predictor.

Conclusion

Using predictive factors identified in our review in context of scoring system may help in the early detection of locoregional recurrence after TME. This may help in tailoring the application of intensive follow-up programs.

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References

  1. Arbman G, Nilsson E, Hallböök O, Sjödahl R (1996) Local recurrence following total mesorectal excision for rectal cancer. Br J Surg 83(3):375–379

    Article  CAS  PubMed  Google Scholar 

  2. Palmer G, Martling A, Cedermark B, Holm T (2007) A population-based study on the management and outcome in patients with locally recurrent rectal cancer. Ann Surg Oncol 14(2):447–454

    Article  CAS  PubMed  Google Scholar 

  3. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJ, Pahlman L, Glimelius B, van Krieken JHJ (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345(9):638–646

    Article  CAS  PubMed  Google Scholar 

  4. Stevenson AR, Solomon MJ, Brown CS, Lumley JW, Hewett P, Clouston AD, Gebski VJ, Wilson K, Hague W, Simes J (2019) Disease-free survival and local recurrence after laparoscopic-assisted resection or open resection for rectal cancer: the Australasian laparoscopic cancer of the rectum randomized clinical trial. Ann Surg 269(4):596–602

    Article  PubMed  Google Scholar 

  5. Mahvi DA, Liu R, Grinstaff MW, Colson YL, Raut CP (2018) Local cancer recurrence: the realities, challenges, and opportunities for new therapies. Cancer J Clin 68(6):488–505

    Article  Google Scholar 

  6. Platell C, Spilsbury K (2014) Influence of local recurrence on survival in patients with rectal cancer. ANZ J Surg 84(1–2):85–90

    Article  PubMed  Google Scholar 

  7. Baca B, Beart RW Jr, Etzioni DA (2011) Surveillance after colorectal cancer resection: a systematic review. Dis Colon Rectum 54(8):1036–1048

    Article  PubMed  Google Scholar 

  8. Tjandra JJ, Chan MK (2007) Follow-up after curative resection of colorectal cancer: a meta-analysis. Dis Colon Rectum 50(11):1783–1799

    Article  PubMed  Google Scholar 

  9. Macafee D, Whynes D, Scholefield J (2008) Risk-stratified intensive follow up for treated colorectal cancer–realistic and cost saving? Colorectal Dis 10(3):222–230

    Article  CAS  PubMed  Google Scholar 

  10. Secco GB, Fardelli R, Gianquinto D, Bonfante P, Baldi E, Ravera G, Derchi L, Ferraris R (2002) Efficacy and cost of risk-adapted follow-up in patients after colorectal cancer surgery: a prospective, randomized and controlled trial. Eur J Surg Oncol (EJSO) 28(4):418–423

    Article  Google Scholar 

  11. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269

    Article  PubMed  Google Scholar 

  12. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 358:j4008

    Article  PubMed  PubMed Central  Google Scholar 

  13. Emile SH, Magdy A, Elnahas W, Hamdy O, Abdelnaby M, Khafagy W (2018) Predictors for local recurrence and distant metastasis of mucinous colorectal adenocarcinoma. Surgery 164(1):56–65

    Article  Google Scholar 

  14. Lin H-H, Lin J-K, Lin C-C, Lan Y-T, Wang H-S, Yang S-H, Jiang J-K, Chen W-S, Lin T-C, Liang W-Y (2013) Circumferential margin plays an independent impact on the outcome of rectal cancer patients receiving curative total mesorectal excision. Am J Surg 206(5):771–777

    Article  PubMed  Google Scholar 

  15. Franz C, Lang HM, Ghamarnejad O et al (2020) Prognostic impact of ventral versus dorsal tumor location after total mesorectal excision of rectal cancer. Ann Surg Oncol 27:430–438

    Article  PubMed  Google Scholar 

  16. Baek JY, Yu JI, Park HC, Choi DH, Yoo GS, Cho WK, Lee W-Y, Yun SH, Cho YB, Park YA (2019) Risk factors for locoregional recurrence in patients with pathologic T3N0 rectal cancer with negative resection margin treated by surgery alone. Rad Oncol J 37(2):110

    Article  Google Scholar 

  17. Räsänen M, Renkonen-Sinisalo L, Mustonen H, Lepistö A (2019) Is there a need for neoadjuvant short-course radiotherapy in T3 rectal cancer with positive lymph node involvement? A single-center retrospective cohort study. World J Surg Oncol 17(1):139

    Article  PubMed  PubMed Central  Google Scholar 

  18. Peeters KC, Marijnen CA, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T, Rutten H, Pahlman L, Glimelius B, Leer JW (2007) The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246(5):693–701

    Article  PubMed  Google Scholar 

  19. Folkesson J, Birgisson H, Pahlman L, Cedermark B, Glimelius B, Gunnarsson U (2005) Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 23(24):5644–5650

    Article  PubMed  Google Scholar 

  20. Yamamoto T, Kawada K, Hida K, Ganeko R, Inamoto S, Yoshitomi M, Watanabe T, Sakai Y (2019) Optimal treatment strategy for rectal cancer based on the risk factors for recurrence patterns. Int J Clin Oncol 24(6):677–685

    Article  PubMed  Google Scholar 

  21. Nagasaki T, Akiyoshi T, Fujimoto Y, Konishi T, Nagayama S, Fukunaga Y, Ueno M (2017) Preoperative chemoradiotherapy might improve the prognosis of patients with locally advanced low rectal cancer and lateral pelvic lymph node metastases. World J Surg 41(3):876–883

    Article  PubMed  Google Scholar 

  22. Kim N-K, Kim Y-W, Min B-S, Lee K-Y, Sohn S-K, Cho C-H (2009) Factors associated with local recurrence after neoadjuvant chemoradiation with total mesorectal excision for rectal cancer. World J Surg 33(8):1741–1749

    Article  PubMed  Google Scholar 

  23. Yun H, Lee L, Park J, Cho Y, Cho Y, Lee W, Kim H, Chun H, Yun S (2008) Local recurrence after curative resection in patients with colon and rectal cancers. Int J Colorectal Dis 23(11):1081–1087

    Article  CAS  PubMed  Google Scholar 

  24. Bernstein T, Endreseth B, Romundstad P, Wibe A, Registry NCC (2012) Improved local control of rectal cancer reduces distant metastases. Colorectal Dis 14(10):e668–e678

    Article  CAS  PubMed  Google Scholar 

  25. Law WL, Chu KW (2002) Local recurrence following total mesorectal excision with double-stapling anastomosis for rectal cancers: analysis of risk factors. World J Surg 26(10):1272

    Article  PubMed  Google Scholar 

  26. Kim YW, Kim NK, Min BS, Huh H, Kim JS, Kim JY, Sohn SK, Cho CH (2009) Factors associated with anastomotic recurrence after total mesorectal excision in rectal cancer patients. J Surg Oncol 99(1):58–64

    Article  PubMed  Google Scholar 

  27. Bernstein T, Endreseth B, Romundstad P, Wibe A, Registry NCC (2012) What is a safe distal resection margin in rectal cancer patients treated by low anterior resection without preoperative radiotherapy? Colorectal Dis 14(2):e48–e55

    Article  CAS  PubMed  Google Scholar 

  28. Deng Y (2017) Rectal cancer in Asian vs. Western countries: why the variation in incidence. Curr Treat Options Oncol 18(10):64

    Article  PubMed  Google Scholar 

  29. Doyle TJ, Zheng W, Cerhan JR, Hong C-P, Sellers TA, Kushi LH, Folsom AR (1997) The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. Am J Public Health 87(7):1168–1176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Gunderson LL, Sargent DJ, Tepper JE, Wolmark N, O'Connell MJ, Begovic M, Allmer C, Colangelo L, Smalley SR, Haller DG (2004) Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol 22(10):1785–1796

    Article  PubMed  Google Scholar 

  31. Dresen R, Peters E, Rutten H, Nieuwenhuijzen G, Demeyere T, Van den Brule A, Kessels A, Beets-Tan R, Van Krieken J, Nagtegaal I (2009) Local recurrence in rectal cancer can be predicted by histopathological factors. Eur J Surg Oncol (EJSO) 35(10):1071–1077

    Article  CAS  Google Scholar 

  32. Hogan J, Chang KH, Duff G, Samaha G, Kelly N, Burton M, Burton E, Coffey JC (2015) Lymphovascular invasion: a comprehensive appraisal in colon and rectal adenocarcinoma. Dis Colon Rectum 58(6):547–555

    Article  PubMed  Google Scholar 

  33. Ptok H, Meyer F, Steinert R, Vieth M, Ridwelski K, Lippert H, Gastinger I (2007) No prognostic impact of isolated lymphovascular invasion after radical resection of rectal cancer—results of a multicenter observational study. Int J Colorectal Dis 22(7):749–756

    Article  PubMed  Google Scholar 

  34. Barresi V, Bonetti LR, Vitarelli E, Di Gregorio C, de Leon MP, Barresi G (2012) Immunohistochemical assessment of lymphovascular invasion in stage I colorectal carcinoma: prognostic relevance and correlation with nodal micrometastases. Am J Surg Pathol 36(1):66–72

    Article  PubMed  Google Scholar 

  35. Bosman FT, Carneiro F, Hruban RH, Theise ND (2010) WHO classification of tumours of the digestive system, 4th edn. World Health Organization, Geneva, Switzerland, pp 417 (9789283224327)

  36. Shin US, Yu CS, Kim JH, Kim TW, Lim S-B, Yoon SN, Yoon YS, Kim CW, Kim JC (2011) Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol 18(8):2232–2239

    Article  PubMed  Google Scholar 

  37. McCawley N, Clancy C, O’Neill BD, Deasy J, McNamara DA, Burke JP (2016) Mucinous rectal adenocarcinoma is associated with a poor response to neoadjuvant chemoradiotherapy: a systematic review and meta-analysis. Dis Colon Rectum 59(12):1200–1208

    Article  PubMed  Google Scholar 

  38. Sugarbaker PH (2001) Mucinous colorectal carcinoma. J Surg Oncol 77(4):282–283

    Article  CAS  PubMed  Google Scholar 

  39. Rickles AS, Dietz DW, Chang GJ, Wexner SD, Berho ME, Remzi FH, Greene FL, Fleshman JW, Abbas MA, Peters W (2015) High rate of positive circumferential resection margins following rectal cancer surgery: a call to action. Ann Surg 262(6):891

    Article  PubMed  Google Scholar 

  40. Nagtegaal ID, Quirke P (2008) What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26(2):303–312

    Article  PubMed  Google Scholar 

  41. Wibe A, Rendedal P, Svensson E, Norstein J, Eide T, Myrvold H, Søreide O (2002) Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg 89(3):327–334

    Article  CAS  PubMed  Google Scholar 

  42. Khani MH, Smedh K, Kraaz W (2007) Is the circumferential resection margin a predictor of local recurrence after preoperative radiotherapy and optimal surgery for rectal carcinoma? Colorectal Dis 9(8):706–712

    Article  PubMed  Google Scholar 

  43. Monson J, Weiser M, Buie W, Chang G, Rafferty J, Buie WD, Rafferty J, Guillem J, Boushey R, Chang G (2013) Practice parameters for the management of rectal cancer (revised). Dis Colon Rectum 56(5):535–550

    Article  CAS  PubMed  Google Scholar 

  44. Bujko K, Rutkowski A, Chang GJ, Michalski W, Chmielik E, Kusnierz J (2012) Is the 1-cm rule of distal bowel resection margin in rectal cancer based on clinical evidence? A systematic review. Ann Surg Oncol 19(3):801–808

    Article  PubMed  Google Scholar 

  45. Åsli LM, Johannesen TB, Myklebust TÅ, Møller B, Eriksen MT, Guren MG (2017) Preoperative chemoradiotherapy for rectal cancer and impact on outcomes–A population-based study. Radiother Oncol 123(3):446–453

    Article  PubMed  Google Scholar 

  46. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17):1731–1740

    Article  CAS  PubMed  Google Scholar 

  47. Shihab OC, Brown G, Daniels IR, Heald RJ, Quirke P, Moran BJ (2010) Patients with low rectal cancer treated by abdominoperineal excision have worse tumors and higher involved margin rates compared with patients treated by anterior resection. Dis Colon Rectum 53(1):53–56

    Article  PubMed  Google Scholar 

  48. Marr R, Birbeck K, Garvican J, Macklin CP, Tiffin NJ, Parsons WJ, Dixon MF, Mapstone NP, Sebag-Montefiore D, Scott N (2005) The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg 242(1):74

    Article  PubMed  PubMed Central  Google Scholar 

  49. Wibe A, Syse A, Andersen E, Tretli S, Myrvold HE, Søreide O, Group NRC (2004) Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior vs. abdominoperineal resection. Dis Colon Rectum 47(1):48–58

    Article  PubMed  Google Scholar 

  50. Choi Y, Lee Y-H, Park SK, Cho H, Ahn KJ (2016) Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy. Radiat Oncol J 34(2):113

    Article  PubMed  PubMed Central  Google Scholar 

  51. Wu X-Y, Wu Z-F, Cao Q-H, Chen C, Chen Z-W, Xu Z, Li W-S, Liu F-K, Yao X-Q, Li G (2014) Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy. World J Gastroenterol 20(43):16268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Kim S-E, Paik HY, Yoon H, Lee JE, Kim N, Sung M-K (2015) Sex-and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 21(17):5167

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

    Sualeh Muslim Khan & Syed Osama Ahsan

  2. Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

    Sameh Hany Emile & Samer Hani Barsom

Authors
  1. Sualeh Muslim Khan
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  2. Sameh Hany Emile
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  3. Samer Hani Barsom
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  4. Syed Osama Ahsan
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Contributions

Sualeh Muslim Khan designed the study, searched the literature, extracted the data, interpreted the data, Wrote the first draft. Sameh Hany Emile, Searched literature, assessed the quality of studies, analyzed the data and critically revised the manuscript. Samer Hani Barsoum, contributed to data analysis interpretation, critically revising the manuscript and final approval of article. Syed Osama Ahsan. Extracted the data, assessed the quality of studies and contributed to data interpretation. All mentioned authors gave permission for final approval of manuscript for submission.

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Correspondence to Sualeh Muslim Khan.

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Khan, S.M., Emile, S.H., Barsom, S.H. et al. Development of the ‘PREDICT’ score through a systematic review and meta-analysis of the predictive parameters for locoregional recurrence after total mesorectal excision. Updates Surg 73, 35–46 (2021). https://doi.org/10.1007/s13304-020-00853-z

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  • DOI: https://doi.org/10.1007/s13304-020-00853-z

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