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Updates in Surgery

, Volume 70, Issue 1, pp 23–31 | Cite as

The impact of log odds of positive lymph nodes (LODDS) in colon and rectal cancer patient stratification: a single-center analysis of 323 patients

  • Andrea Scarinci
  • Tatiana Di Cesare
  • Daniele Cavaniglia
  • Tiziano Neri
  • Michelle Colletti
  • Giulia Cosenza
  • Andrea Liverani
Original Article
  • 70 Downloads

Abstract

Log odds of positive nodes (LODDS), defined as the log of the ratio between the number of positive nodes and the number of negative nodes, has been recently introduced as a tool in predicting prognosis. This study aims to establish the effective and prognostic value of LODDS in predicting the survival outcome of CRC patients undergoing surgical resection. The study population is represented by 323 consecutive patients with primary colon or rectal adenocarcinoma thatunderwent curative resection. LODDS values were calculated by empirical logistic formula, log(pnod + 0.5)/(tnod − pnod + 0.5). It was defined as the log of the ratio between the number of positive nodes and the number of negative nodes. The patients were divided into three groups: LODDS0 (≤ − 1.36), LODDS1 (> − 1.36 ≤ − 0.53) and LODDS2 (> − 0.53). Kaplan–Meier curve analyses showed 3-year OS rates of the patients staged by LODDS classification. These values were 88.3, 74.8 and 61.8% for LODDS0, LODDS1 and LODDS2, respectively (P ≤ 0.001). In a multivariate analysis, LODDS is an independent prognostic factor of 3-year OS. This is in contrast to pN stage and lymph node ratio, which shows no statistical significance. ROC analyses showed that LODDS predicted OS better than lymph node ratio. LODDS classification has a better prognostic effect than pN stage and lymph node ratio. LODDS offers a finer stratification and accurately predicts survival of CRC patients.

Keywords

Colon cancer Rectum cancer LODDS Adenocarcinoma Lymph nodes 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that there is no potential conflict of interest.

Research involving human participants and/or animals

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (Institutional and National) and with the Helsinki Declaration of 1964 and later versions.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Copyright information

© Italian Society of Surgery (SIC) 2018

Authors and Affiliations

  • Andrea Scarinci
    • 1
  • Tatiana Di Cesare
    • 1
  • Daniele Cavaniglia
    • 1
  • Tiziano Neri
    • 1
  • Michelle Colletti
    • 2
  • Giulia Cosenza
    • 1
  • Andrea Liverani
    • 1
  1. 1.Department of General SurgeryRegina Apostolorum HospitalRomeItaly
  2. 2.Department of Surgery, Colorectal ServiceMemorial Sloan Kettering Cancer CenterNew YorkUSA

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