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Updates in Surgery

, Volume 70, Issue 1, pp 33–39 | Cite as

Preoperative platelet–lymphocyte ratio is an independent factor of poor prognosis after curative surgery for colon cancer

  • Martin Bailon-Cuadrado
  • Ekta Choolani-Bhojwani
  • Francisco J. Tejero-Pintor
  • Javier Sanchez-Gonzalez
  • Mario Rodriguez-Lopez
  • Baltasar Perez-Saborido
  • Jose L. Marcos-Rodriguez
Original Article
  • 85 Downloads

Abstract

Interaction between tumour and host triggers a systemic inflammatory response. This situation has been associated to cancer progression. Several peripheral blood inflammatory scores have been recently developed, as PLR. Data about the relationship between these scores and cancer prognosis are contradictory. Therefore, the aim of our work is to evaluate the capability of PLR to predict long-term outcomes (OS and RFS) in patients who underwent curative surgery for colon cancer. A retrospective study was designed with patients who underwent curative surgery for colon cancer between September 2008 and January 2012 at Rio Hortega University Hospital, Valladolid (Spain). We analysed the influence of PLR and other clinical variables on OS and RFS. Finally, 201 patients were analysed. Optimal cut-off value for PLR, established with ROC curves, was 153. 1-, 3- and 5-year OS were: 99.0, 90.4 and 82.3% for low PLR, and 93.8, 74.9 and 61.9% for high PLR, p < 0.001. 1-, 3- and 5-year RFS were: 92.4, 84.7 and 77.6% for low PLR, and 83.3, 64.5 and 52.6% for high PLR, p < 0.001. In MVA, high PLR was an independent negative prognostic factor for OS (HR = 2.11; 95% CI 1.22–3.66; p = 0.008) and RFS (HR = 1.99; 95% CI 1.19–3.34; p = 0.009). PLR represents an independent negative prognostic factor for OS and RFS in our sample of patients who underwent curative surgery for colon cancer. However, further studies with a larger sample size from different populations are necessary to confirm this conclusion.

Keywords

Colon cancer Platelet/lymphocyte ratio Overall survival Relapse-free survival 

Notes

Author contributions

We declare every author has actively participated in the drafting and design of this manuscript. We declare every author is pleased with the final version of this manuscript.

Compliance with ethical standards

Funding information

No funds or Grants have been provided.

Consent for publication

Every patient has given permission for publication of information from the medical history as long as it is used for medical research purposes.

Conflict of interest

The authors declare that they have no conflict of interest. No funds or grants have been provided.

Research involving human participants and/or animals

We have performed an observational retrospective study in which we have not modified the usual treatment of this disease, so disclosures about human research (in the sense of a clinical trial) are not applicable. No animal has been involved in this study.

Informed consent

Every patient has signed the informed consent for surgery. In addition, every patient has given permission for publication of information from the medical history as long as it is used for medical research purposes.

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Copyright information

© Italian Society of Surgery (SIC) 2017

Authors and Affiliations

  • Martin Bailon-Cuadrado
    • 1
  • Ekta Choolani-Bhojwani
    • 1
  • Francisco J. Tejero-Pintor
    • 1
  • Javier Sanchez-Gonzalez
    • 1
  • Mario Rodriguez-Lopez
    • 1
  • Baltasar Perez-Saborido
    • 1
  • Jose L. Marcos-Rodriguez
    • 1
  1. 1.General and Digestive Surgery DepartmentRio Hortega University HospitalValladolidSpain

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