Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets
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Oral squamous cell carcinoma (OSCC) is a highly prevalent cancer worldwide, and OSCC often goes undiagnosed until advanced disease is present, which contributes to a low survival rate for OSCC patients. The identification of biomarkers for the early detection OSCC and novel therapeutic targets for OSCC treatment is an important research objective. We performed bioinformatics analyses of the gene expression profile of OSCC using microarray data to identify genes that contribute to the development of OSCC. We also predicted the transcription factors involved in the regulation of differential gene expression in OSCC. Our results showed that PI3K, EGFR, STAT1, and CPBP are important contributors to the changes in cellular physiology that occur during the development of OSCC. Therefore, these genes represent potential diagnostic biomarkers and therapeutic targets for OSCC.
KeywordsHead and neck squamous cell carcinoma (HNSCC) Oral squamous cell carcinoma (OSCC) Differentially expressed gene (DEG) Healthy oral squamous cell (HOSC)
Funding for this study was provided by Zhongshan Hospital, Fudan University.
Compliance with ethical standards
Our study was approved by the Hospital Ethics Committee of Zhongshan Hospital and Fudan University (Shanghai, China), which determined that patient consent was not required for our analysis of publicly available data sets.
Conflict of interest
- 4.Boyle P, Levin B. World cancer report 2008. IARC Press, International Agency for Research on Cancer; 2008.Google Scholar
- 6.Mazumder TH, Nath S, Nath N, Kumar M. Head and neck squamous cell carcinoma: prognosis using molecular approach. Central European Journal of Biology. 2014;9:593–613.Google Scholar
- 32.van Breda SG, Claessen SM, Lo K, van Herwijnen M, Brauers KJ, Lisanti S et al. Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis. Arch Toxicol. 2014.Google Scholar
- 43.Yap L, Lee D, Khairuddin A, Pairan M, Puspita B, Siar C et al. The opposing roles of NOTCH signalling in head and neck cancer: a mini review. Oral Dis. 2015.Google Scholar
- 44.Vincent-Chong VK, Salahshourifar I, Karen-Ng LP, Siow MY, Kallarakkal TG, Ramanathan A et al. Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma. Scientific World Journal. 2014;2014:897523.Google Scholar
- 46.CQ X, Zhu ST, Wang M, Guo SL, Sun XJ, Cheng R, et al. Pathway analysis of differentially expressed genes in human esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2015;19:1652–61.Google Scholar
- 61.Shin JA, Ryu MH, Kwon KH, Choi B, Cho SD. Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines. J Oral Pathol Med. 2014.Google Scholar
- 65.Yu C-C, Huang H-b, Hung S-K, Liao H-F, Lee C-C, Lin H-Y et al. AZD2014 radiosensitizes oral squamous cell carcinoma by inhibiting AKT/mTOR axis and inducing G1/G2/M cell cycle arrest. PLoS ONE. 2016, 11.Google Scholar
- 66.Su Y-C, Yu C-C, Hung S-K, Lin H-Y, Chan MW-Y, Huang H-B et al., editors. Effect of NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, on radiosensitivity of oral cancer cell line through G2/M phase checkpoint regulation. ASCO Annual Meeting Proceedings; 2014.Google Scholar