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Diverse roles of miR-335 in development and progression of cancers

  • Review
  • Published:
Tumor Biology

Abstract

MicroRNAs (miRNAs), a series of small noncoding RNAs that regulate gene expression at the post-transcriptional/translational level, are pivotal in cell differentiation, biological development, occurrence, and development of diseases, especially in cancers. Early studies have shown that miRNA-335 (miR-335) is widely dysregulated in human cancers and play critical roles in tumorigenesis and tumor progression. In this review, we aim to summarize the regulation of miR-335 expression mechanisms in cancers. We focus on the target genes regulated by miR-335 and its downstream signaling pathways involved in the biological effects of tumor growth, invasion, and metastasis both in vitro and in vivo, and analyze the relationships between miR-335 expression and the clinical characteristics of tumors as well as its effects on prognosis. The collected evidences support the potential use of miR-335 in prognosis and diagnosis as well as the therapeutic prospects of miR-335 in cancers.

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Acknowledgments

This project is funded by National High Technology Research and Development Program of China (No. 2014AA020604), the National Natural Science Foundation of China (No. 81272470), the National key clinical specialist construction Programs of China (No. 2013[544]), Major Program of Natural Science Foundation of Jiangsu Province (No. BL2014090), and Natural Science Foundation of Jiangsu Province (No. BK20151579).

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Authors and Affiliations

  1. Department of General Surgery, Xuzhou Medical University, Xuzhou, Jiangsu, China

    Long-ji Luo & Fan Yang

  2. Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Baiziting 42, Nanjing, 210009, China

    Long-ji Luo, Dan-dan Wang, Jing Wang, Fan Yang & Jin-hai Tang

  3. Nanjing Medical University, Nanjing, Jiangsu, China

    Dan-dan Wang & Jing Wang

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  1. Long-ji Luo
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Correspondence to Jin-hai Tang.

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Luo, Lj., Wang, Dd., Wang, J. et al. Diverse roles of miR-335 in development and progression of cancers. Tumor Biol. 37, 15399–15410 (2016). https://doi.org/10.1007/s13277-016-5385-3

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