Tumor Biology

, Volume 36, Issue 11, pp 8903–8911 | Cite as

Preoperative D-dimers as an independent prognostic marker in cervical carcinoma

  • Yao-Ling Luo
  • Pei-Dong Chi
  • Xin Zheng
  • Lin Zhang
  • Xue-Ping Wang
  • Hao Chen
Research Article


Activation of coagulation and fibrinolysis has been observed in many tumors. Our study aimed to investigate the clinical and prognostic significance of various plasma coagulation tests in patients with cervical cancer. A total of 296 patients with cervical cancer were included in the analysis. Patients were followed up for at least 60 months until death. Pretreatment parameters including activated partial thromboplastin time, D-dimer, fibrinogen, prothrombin time, thrombin time, lactate dehydrogenase, and squamous cell carcinoma antigen were evaluated. Prothrombin time (hazard ratio = 1.825; P = 0.006) and plasma D-dimer levels (hazard ratio = 2.179; P = 0.036) were identified as significant independent predictors of overall survival. Patients with elevated D-dimer levels had a significantly shorter overall survival compared with those with low-D-dimer levels (<0.5 μg/ml) in the stage I subgroup (n = 98, P = 0.019) and stage II subgroup (n = 77, P = 0.044). D-dimer levels differed significantly according to mortality (P < 0.001), stage I versus stage II (P = 0.030), and stage I versus stage III/IV (P = 0.038). DD level of patients with chemotherapy and/or radiotherapy was higher than patients with other treatment (P < 0.001). Patients with a low-D-dimer level (<0.5 μg/ml) showed a significantly better 5-year overall survival (OS) compared with patients with an increased D-dimer level for different histological typing of squamous cell carcinoma (SCC) (P = 0.001) and non-SCC (P < 0.043). In conclusion, the pretreatment plasma D-dimer level is a potential prognostic factor for cervical cancer.


Cervical cancer Coagulation Prothrombin time D-dimer Prognosis 



We thank the Director of Clinical Laboratories, Sun Yat-sen University Cancer Center, Guangzhou, China, Prof. Wan-Li Liu, for providing support on research conditions in this study and making substantial contributions to its conception and design.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yao-Ling Luo
    • 1
  • Pei-Dong Chi
    • 1
  • Xin Zheng
    • 1
  • Lin Zhang
    • 1
  • Xue-Ping Wang
    • 1
  • Hao Chen
    • 1
  1. 1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina

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