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RETRACTED ARTICLE: A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Although matrix metalloproteinase 14 (MMP-14) has been shown to play a substantial role in the carcinogenesis of some types of cancer, its involvement in the pathogenesis of nasopharyngeal carcinoma (NPC) has not been reported. Here, we analyzed MMP-14 levels in the NPC specimens from patients and compared with the paired normal nasopharynx (NNP) tissues. We found that NPC had significantly higher messenger RNA (mRNA) and protein levels of MMP-14. Moreover, higher levels of MMP-14 correlated with more advanced status of clinical stage and lymphatic metastasis. In vitro, MMP-14 levels determined the potential of invasiveness of NPC cells, possibly through induction of EMT-associated genes. Our data thus highlight MMP-14 as a novel therapeutic target for NPC.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164 Lanxi Road, Shanghai, 200062, China

    Jian Zhao, Zhongyu Kong, Feng Xu & Wei Shen

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  1. Jian Zhao
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  2. Zhongyu Kong
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  3. Feng Xu
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  4. Wei Shen
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Corresponding author

Correspondence to Wei Shen.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Zhao, J., Kong, Z., Xu, F. et al. RETRACTED ARTICLE: A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma. Tumor Biol. 36, 8609–8615 (2015). https://doi.org/10.1007/s13277-015-3558-0

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  • DOI: https://doi.org/10.1007/s13277-015-3558-0

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