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RETRACTED ARTICLE: Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Gastric cancer (GC) is the fourth most common malignant human cancer. So far, the molecular mechanisms underlying the tumorigenesis of GC are not completely understood. Here, we reported significantly higher levels of serum insulin-like growth factor (IGF)-1 in GC patients and significantly higher levels of phosphorylated IGF-1 receptor (IGF-1R) in the GC specimen. Moreover, IGF-1 induced phosphorylation of IGF-1R and then phosphorylation of its downstream factor Akt in the GC cells. Further, IGF-1/Akt-induced forkhead box protein O1 (FoxO1) nuclear exclusion, but not IGF-1/Akt-induced mTOR phosphorylation, was essential for the augment in GC cell growth. Together, IGF-1/Akt/FoxO1 regulatory machinery appears to be a previously unappreciated signaling axis involved in the carcinogenesis of GC.

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Authors and Affiliations

  1. Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, 250014, China

    Shuangling Li, Xiaofei Lei, Jianna Zhang, Hongli Yang & Changqing Xu

  2. Shandong University School of Medicine, Jinan, 250012, China

    Shuangling Li

  3. Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, 250021, China

    Jiyong Liu

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  1. Shuangling Li
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  2. Xiaofei Lei
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  3. Jianna Zhang
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  4. Hongli Yang
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  5. Jiyong Liu
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  6. Changqing Xu
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Corresponding authors

Correspondence to Jiyong Liu or Changqing Xu.

Additional information

Shuangling Li and Xiaofei Lei equally contributed in this study.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Li, S., Lei, X., Zhang, J. et al. RETRACTED ARTICLE: Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention. Tumor Biol. 36, 4519–4523 (2015). https://doi.org/10.1007/s13277-015-3096-9

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  • DOI: https://doi.org/10.1007/s13277-015-3096-9

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