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Vascular endothelial growth factor -634G/C and vascular endothelial growth factor -2578C/A polymorphisms and lung cancer risk: a case–control study and meta-analysis

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Tumor Biology

Abstract

Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis. In present study, we conducted a case–control study and meta-analysis to evaluate the genetic effects of VEGF -634G/C and VEGF -2578C/A polymorphisms and risk of lung cancer. A total of 175 subjects were recruited for case–control study and seven studies were included in the meta-analysis. Our case–control study showed that VEGF -634G/C polymorphism had no association with lung cancer risk (CC vs. GG: OR = 0.88, 95 % CI = 0.37–2.11), whereas there was an association between VEGF -2578CC genotype and decrease in lung cancer risk (CC vs. CA/AA: OR = 0.52, 95 % CI = 0.28–0.96). A meta-analysis was further performed and statistically similar results were obtained (CC vs. GG: OR = 0.91, 95 % CI = 0.60–1.39 for VEGF −634; CC vs. AA: OR = 0.53, 95 % CI = 0.32–0.89 for VEGF −2578). Our study showed that the variant genotypes of the VEGF -2578C/A polymorphism, but not the VEGF -634G/C polymorphism, was associated with lung cancer risk. More studies are needed to detect VEGF -634G/C and VEGF −2578 polymorphisms and their association with lung cancer in different ethnic populations incorporated with environmental exposures.

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References

  1. Yokota J, Kohno T. Molecular footprints of human lung cancer progression. Cancer Sci. 2004;95:197–204.

    Article  PubMed  CAS  Google Scholar 

  2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.

    Article  PubMed  Google Scholar 

  3. Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer. 2001;37 Suppl 8:4–66.

    Article  Google Scholar 

  4. Xing D, Tan W, Wei Q, Lin D. Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. Lung Cancer. 2002;38:123–9.

    Article  PubMed  Google Scholar 

  5. Cao C, Zhang YM, Wang R, Sun SF, Chen ZB, Ma HY, et al. Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis. Chin Med J (Engl). 2011;124:2203–8.

    PubMed  CAS  Google Scholar 

  6. Dong J, Dai J, Shu Y, Pan S, Xu L, Chen W, et al. Polymorphisms in EGFR and VEGF contribute to non-small-cell lung cancer survival in a Chinese population. Carcinogenesis. 2010;31:1080–6.

    Article  PubMed  CAS  Google Scholar 

  7. Lee SJ, Lee SY, Jeon HS, Park SH, Jang JS, Lee GY, et al. Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:571–5.

    Article  PubMed  CAS  Google Scholar 

  8. Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, et al. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res. 2008;14:612–7.

    Article  PubMed  CAS  Google Scholar 

  9. Sun SF, Huang DB, Cao C, Deng ZC. Polymorphism of VEGF-460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population. Med Oncol. 2013;30(1):410.

    Article  PubMed  CAS  Google Scholar 

  10. Cao C, Fang JJ, Ying T, Sun SF, Lv D, Chen ZB, et al. Vascular endothelial growth factor +936C/T and +405G/C polymorphisms and cancer risk: a meta-analysis. Arch Med Res. 2010;41:548–57.

    Article  PubMed  CAS  Google Scholar 

  11. Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, et al. A common polymorphism in the 5′-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes. 2002;51:1635–9.

    Article  PubMed  CAS  Google Scholar 

  12. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol. 2002;13:260–4.

    PubMed  CAS  Google Scholar 

  13. Cao C, Ying T, Fang JJ, Sun SF, Lv D, Chen ZB, et al. Polymorphism of vascular endothelial growth factor -2578C/A with cancer risk: evidence from 11263 subjects. Med Oncol. 2011;28:1169–75.

    Article  PubMed  CAS  Google Scholar 

  14. Kim EJ, Jeong P, Quan C, Kim J, Bae SC, Yoon SJ, et al. Genotypes of TNF-alpha, VEGF, hOGG1, GSTM1, and GSTT1: useful determinants for clinical outcome of bladder cancer. Urology. 2005;65:70–5.

    Article  PubMed  Google Scholar 

  15. Cao C, Wang J, Bunjhoo H, Xu Y, Fang H. Risk profile of bevacizumab in patients with non-small cell lung cancer: a meta-analysis of randomized controlled trials. Acta Oncol. 2012;51:151–6.

    Article  PubMed  CAS  Google Scholar 

  16. Naik NA, Bhat IA, Afroze D, Rasool R, Mir H, Andrabi SI, et al. Vascular endothelial growth factor A gene (VEGFA) polymorphisms and expression of VEGFA gene in lung cancer patients of Kashmir Valley (India). Tumour Biol. 2012;33:833–9.

    Article  PubMed  CAS  Google Scholar 

  17. Naykoo NA, Hameed I, Aasif M, Shaffi S, Yousuf Q, Bhat IA, et al. Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma. Gene. 2013 In press.

  18. Li Y, Liang J, Liu X, Liu H, Yin B, Xiao J, et al. Correlation of polymorphisms of the vascular endothelial growth factor gene and the risk of lung cancer in an ethnic Han group of North China. Exp Ther Med. 2012;3:673–6.

    PubMed Central  PubMed  CAS  Google Scholar 

  19. Liang J, Yu X, Liu X, Sun D, Liu H, Hu W, et al. Vascular endothelial growth factor polymorphisms and risk of lung cancer. Chinese-German Journal of Clinical Oncology. 2009;8:269–72.

    Article  CAS  Google Scholar 

  20. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246:1306–9.

    Article  PubMed  CAS  Google Scholar 

  21. McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist. 2000;5 Suppl 1:3–10.

    Article  PubMed  CAS  Google Scholar 

  22. Zhai R, Liu G, Asomaning K, Su L, Kulke MH, Heist RS, et al. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis. 2008;29:2330–4.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  23. Stevens A, Soden J, Brenchley PE, Ralph S, Ray DW. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res. 2003;63:812–6.

    PubMed  CAS  Google Scholar 

  24. Ding QL, Sun SF, Cao C, Deng ZC. Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: a meta-analysis involving 11,897 subjects. J Asthma. 2012;49:557–62.

    Article  PubMed  CAS  Google Scholar 

  25. Winchester EC, Millwood IY, Rand L, Penny MA, Kessling AM. Association of the TNF-alpha-308 (G – > A) polymorphism with self-reported history of childhood asthma. Hum Genet. 2000;107:591–6.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by the grant of Natural Science Foundation of Ningbo (no. 2012A610257, for ZC Deng) and grant of Social Development of Science and Technology Project of Ningbo (no. 2011C50025, for C Cao)

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Authors and Affiliations

  1. Department of Respiratory Medicine, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, Zhejiang, China

    Zai-Chun Deng, Chao Cao, Yi-Ming Yu & Hong-Ying Ma

  2. Department of Medical Oncology, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, Zhejiang, China

    Meng Ye

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  1. Zai-Chun Deng
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  2. Chao Cao
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  3. Yi-Ming Yu
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  4. Hong-Ying Ma
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Correspondence to Meng Ye.

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Deng, ZC., Cao, C., Yu, YM. et al. Vascular endothelial growth factor -634G/C and vascular endothelial growth factor -2578C/A polymorphisms and lung cancer risk: a case–control study and meta-analysis. Tumor Biol. 35, 1805–1811 (2014). https://doi.org/10.1007/s13277-013-1241-x

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  • DOI: https://doi.org/10.1007/s13277-013-1241-x

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