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RETRACTED ARTICLE: Comprehensive assessment of the association between tumor necrosis factor alpha G238A polymorphism and liver cancer risk

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Tumor necrosis factor alpha (TNF-α) has been suggested to play an important role in the development and liver cancer. TNF-α 238 G/A polymorphism was hypothesized to increase the risk of liver cancer, but findings from previous studies were controversial. To explore a more precise estimation of the relationship between TNF-α 238 G/A polymorphism and liver cancer, we performed a meta-analysis. PubMed, Embase, and China Biology Medicine databases were searched for all publications on this association through March 12, 2013. Odds ratios (ORs) with its 95 % confidence intervals (CIs) were used to assess the strength of this association. Eleven studies with 1,406 liver cancer cases and 2,386 noncancer controls were included into this meta-analysis. Overall, there was a significant association between TNF-α 238 G/A polymorphism and increased risk of liver cancer under all three genetic models (A vs. G, OR 1.51, 95 % CI 1.20–1.89, P < 0.001, I 2 = 37.7 %; AG vs. GG, OR 1.49, 95 % CI 1.01–2.21, P = 0.045, I 2 = 53.2 %; AA/AG vs. GG, OR 1.76, 95 % CI 1.35–2.30, P < 0.001, I 2 = 36.5 %). The sensitivity analysis further strengthened the validity of the positive association. Subgroup analysis of nine studies from Asian countries showed that there was a significant association between TNF-α 238 G/A polymorphism and increased risk of liver cancer in Asians (A vs. G, OR 1.35, 95 % CI 1.03–1.76, P = 0.027, I 2 = 40.2 %; AA/AG vs. GG, OR 1.56, 95 % CI 1.14–2.15, P = 0.006, I 2 = 41.9 %). In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of liver cancer, especially in Asians.

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Authors and Affiliations

  1. Molecular Oncology Department of Cancer Research Institution, The First Hospital, China Medical University, Shenyang, 110001, China

    Xin Tian, Ping Ma, Chengguang Sui, Yan Li, Liye Fu, Tao Jiang, Yang Wang & Youhong Jiang

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  1. Xin Tian
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  2. Ping Ma
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  3. Chengguang Sui
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  4. Yan Li
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Correspondence to Youhong Jiang.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6

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Tian, X., Ma, P., Sui, C. et al. RETRACTED ARTICLE: Comprehensive assessment of the association between tumor necrosis factor alpha G238A polymorphism and liver cancer risk. Tumor Biol. 35, 103–109 (2014). https://doi.org/10.1007/s13277-013-1012-8

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  • DOI: https://doi.org/10.1007/s13277-013-1012-8

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