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RETRACTED ARTICLE: LEP gene variant is associated with prostate cancer but not with colorectal cancer

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

The leptin (LEP) gene has been considered to be implicated in the development of cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of LEP rs7799039 variant with colorectal and prostate cancer risk. Published literatures from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed or random effects model. A total of five studies (2,596 colorectal cancer cases and 3,240 controls) for association of LEP rs7799039 variant with colorectal cancer, and three studies (1,343 prostate cancer cases and 1,238 controls) for association with prostate cancer were included in the meta-analysis. For colorectal cancer, there was no significant association of LEP rs7799039 variant with this disease under homogeneous co-dominant model (OR = 0.88, 95 % CI = 0.75–1.02), heterogeneous co-dominant model (OR = 1.00, 95 % CI = 0.89–1.13) and dominant model (OR = 0.97, 95 % CI = 0.87–1.08); however, there was a marginal association under recessive model (OR = 0.87, 95 % CI = 0.76–0.99). For prostate cancer, there was significant association of LEP rs7799039 variant with this disease under homogeneous co-dominant model (OR = 1.33, 95 % CI = 1.06–1.67) and recessive model (OR = 1.26, 95 % CI = 1.05–1.51), but not under heterogeneous co-dominant model (OR = 1.24, 95 % CI = 0.87–1.77) and dominant model (OR = 1.30, 95 % CI = 1.84). The present meta-analysis demonstrated that the LEP rs7799039 variant was associated with prostate cancer, but not with colorectal cancer.

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Authors and Affiliations

  1. Department of Pharmacy, Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China

    Juan He & Guili Xu

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  1. Juan He
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  2. Guili Xu
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Correspondence to Guili Xu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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He, J., Xu, G. RETRACTED ARTICLE: LEP gene variant is associated with prostate cancer but not with colorectal cancer. Tumor Biol. 34, 3131–3136 (2013). https://doi.org/10.1007/s13277-013-0881-1

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  • DOI: https://doi.org/10.1007/s13277-013-0881-1

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