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Evaluation of Bremsstrahlung radiation dose in stereotactically radiocolloid therapy of cystic craniopharyngioma tumors with 32P radio-colloid

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Abstract

Over 90% of craniopharyngeal brain tumors are cystic, which enables the injection of beta emitters such as phosphorus-32 (32P) radio-colloid into cysts for their treatment. The aim of this study was to evaluate the clinical and theoretical modelling of Bremsstrahlung radiation dose resulting from stereotactic radio-colloid therapy of cystic craniopharyngioma tumors with 32P. 32P radio-colloid with appropriate activity concentration was injected to a head phantom, and then the Bremsstrahlung radiation spectrum and planar images were obtained using a gamma camera. Both phantom and gamma camera were simulated using MCNPX code, and the results were compared with practical results. Bremsstrahlung radiation spectrum was measured using a handheld gamma spectrometer for two patients treated with stereotactic radio-colloid therapy with 32P in different positions and compared to Monte Carlo simulation. Results of counting and determining sensitivity coefficients in the air and the attenuating environment were obtained. Also, comparing the counting sensitivity from practical and simulation methods indicated the agreement of the data between the two methods. Comparison of the spectra from different positions around patient’s head indicated the ability to use this detector to quantify the activity in the operating room. Selection of the spectrum is important in Bremsstrahlung radiation imaging. We can take advantage of spectrometry measurement using gamma camera, handheld gamma spectrometer for patient, and theoretical modeling with Monte Carlo code to evaluate radiopharmaceutical distribution, leakage, as well as estimate activity and predict therapeutic effects in other adjacent structures and ultimately optimize radio-colloid therapy in cystic craniopharyngeal patients.

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Acknowledgements

We would like to express our gratitude and appreciation to the staff of the Neurosurgery Department of Shohada-e-Tajrish Hospital and the Novin Medical Center for their cooperation in this project.

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Authors and Affiliations

  1. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Maryam Babaei & Dariush Sardari

  2. Department of Medical Physics and Radiation Sciences, Faculty of Paramedicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

    Ruhollah Ghahramani-Asl

  3. Department of Medical Physics and Radiology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Hamid-Reza Sadoughi

  4. Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Sohrab Shahzadi

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  1. Maryam Babaei
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  2. Ruhollah Ghahramani-Asl
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Correspondence to Ruhollah Ghahramani-Asl or Hamid-Reza Sadoughi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of national research committee as well as the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Both patients were approved by the local ethics committee at Shohada-e-Tajrish Hospital and Shahid Beheshti University of Medical Sciences.

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For this type of study, formal consent is not required but written consent was received from both patients.

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Babaei, M., Ghahramani-Asl, R., Sadoughi, HR. et al. Evaluation of Bremsstrahlung radiation dose in stereotactically radiocolloid therapy of cystic craniopharyngioma tumors with 32P radio-colloid. Australas Phys Eng Sci Med 41, 697–711 (2018). https://doi.org/10.1007/s13246-018-0665-4

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  • DOI: https://doi.org/10.1007/s13246-018-0665-4

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