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A Novel Idea to Improve Cardiac Output of Mechanical Circulatory Support Devices by Optimizing Kinetic Energy Transfer Available in Forward Moving Aortic Blood Flow

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Abstract

Mechanical circulatory support devices (MCSDs) have gained widespread clinical acceptance as an effective heart failure (HF) therapy. The concept of harnessing the kinetic energy (KE) available in the forward aortic flow (AOF) is proposed as a novel control strategy to further increase the cardiac output (CO) provided by MCSDs. A complete mathematical development of the proposed theory and its application to an example MCSDs (two-segment extra-aortic cuff) are presented. To achieve improved device performance and physiologic benefit, the example MCSD timing is regulated to maximize the forward AOF KE and minimize retrograde flow. The proof-of-concept was tested to provide support with and without KE control in a computational HF model over a wide range of HF test conditions. The simulation predicted increased stroke volume (SV) by 20% (9 mL), CO by 23% (0.50 L/min), left ventricle ejection fraction (LVEF) by 23%, and diastolic coronary artery flow (CAF) by 55% (3 mL) in severe HF at a heart rate (HR) of 60 beats per minute (BPM) during counterpulsation (CP) support with KE control. The proposed KE control concept may improve performance of other MCSDs to further enhance their potential clinical benefits, which warrants further investigation. The next step is to investigate various assist technologies and determine where this concept is best applied. Then bench-test the combination of kinetic energy optimization and its associated technology choice and finally test the combination in animals.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND, 58102, USA

    Muhammad B. Qureshi, Jacob Glower & Daniel L. Ewert

  2. Department of Bioengineering and CT Surgery, University of Louisville, Louisville, KY, USA

    Steven C. Koenig

Authors
  1. Muhammad B. Qureshi
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  2. Jacob Glower
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  3. Daniel L. Ewert
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  4. Steven C. Koenig
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Correspondence to Daniel L. Ewert.

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Muhammad B. Qureshi, Jacob Glower, Daniel L. Ewert and Steven C. Koenig declare that they have no conflict of interest.

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No human and animal studies were carried out by the authors for this article.

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Associate Editor John Timothy Baldwin and Ajit P. Yoganathan oversaw the review of this article.

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Qureshi, M.B., Glower, J., Ewert, D.L. et al. A Novel Idea to Improve Cardiac Output of Mechanical Circulatory Support Devices by Optimizing Kinetic Energy Transfer Available in Forward Moving Aortic Blood Flow. Cardiovasc Eng Tech 8, 131–144 (2017). https://doi.org/10.1007/s13239-017-0305-2

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  • DOI: https://doi.org/10.1007/s13239-017-0305-2

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