Peptide Materials for Smart Therapeutic Applications

Abstract

Myriad peptides have been reported for utilization as key motives in design of smart therapeutic materials due to their capabilities for selective binding, self-assembly, and bioresponsiveness. In this review, we describe various therapeutic applications of peptides, their derivatives, and their assemblies by employing the bioresponsive characteristics. Peptide materials have been developed for specific targeting or deep tissue penetration. Amphiphilic peptides and their self-assembled materials also have been adopted for the development of therapeutic materials. Furthermore, triggered structural transformation of the self-assemblies of peptides in response to various stimuli in biological environments facilitates diverse therapeutic applications of peptide materials.

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) (NRF-2020R1A2C1013219). C.K. also thanks Inha University for support.

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Correspondence to Chulhee Kim.

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Lee, J., Kim, C. Peptide Materials for Smart Therapeutic Applications. Macromol. Res. 29, 2–14 (2021). https://doi.org/10.1007/s13233-021-9011-x

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Keywords

  • peptides
  • therapeutic materials
  • selective binding
  • self-assembled structures
  • stimuli-responsiveness