Abstract
We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies.
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Acknowledgments: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF- 2015R1A4A1042350 and NRF- 2017R1A2B4008093), a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry Health & Welfare, Republic of Korea (grant number: HI17C0886), and the Catholic University of Korea, Research Fund, 2017.
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Ahn, G.Y., Paik, DH., Jeong, KY. et al. Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy. Macromol. Res. 26, 573–576 (2018). https://doi.org/10.1007/s13233-018-6089-x
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DOI: https://doi.org/10.1007/s13233-018-6089-x