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Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

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Abstract

We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies.

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References

  1. G. R. Dwivedi, A. Maurya, D. K. Yadav, F. Khan, M. P. Darokar, and S. K. Srivastava, Chem. Biol. Drug Des., 86, 272 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. J. Liu, J. Ethnopharmacol., 49, 57 (1995).

    Article  CAS  PubMed  Google Scholar 

  3. G. Janicsák, K. Veres, M. Kállai, and I. Máthé, Chromatographia, 58, 295 (2003).

    Google Scholar 

  4. Y. Ikeda, A. Murakami, and H. Ohigashi, Mol. Nutr. Food Res., 52, 26 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. D. Baricevic, S. Sosa, R. D. Loggia, A. Tubaro, B. Simonovska, A. Krasna, and A. Zupancic, J. Ethnopharmacol., 75, 125 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. H. Y. Hsu, J. J. Yang, and C. C. Lin, Cancer Lett., 111, 7 (1997).

    Article  CAS  PubMed  Google Scholar 

  7. S. L. Yan, C. Y. Huang, S. T. Wu, and M. C. Yin, Toxicol. In Vitro, 24, 842 (2010).

    Article  CAS  PubMed  Google Scholar 

  8. C. Y. Huang, C. Y. Lin, C. W. Tsai, M. C. Yin, Toxicol. In Vitro, 25, 1274 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. I. Bonaccorsi, F. Altieri, I. Sciamanna, E. Oricchio, C. Grillo, G. Contartese, and E. M. Galati, Cancer Lett., 263, 130 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. M. Kondo, S. L. MacKinnon, C. C. Craft, M. D. Matchett, R. A. Hurta, and C. C. Neto, J. Sci. Food Agric., 91, 789 (2011).

    Article  CAS  PubMed  Google Scholar 

  11. A. R. Hedges, Chem. Rev., 98, 2035 (1998).

    Article  CAS  PubMed  Google Scholar 

  12. W. Zhang, D. Hong, Y. Zhou, Y. Zhang, Q. Shen, J. Y. Li, L. H. Hu, and J. Li, Biochim. Biophys. Acta, 1760, 1505 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. X. J. Zhou, X. M. Hu, Y. M. Yi, and J. Wan, Drug Dev. Ind. Pharm., 35, 305 (2009).

    Article  CAS  PubMed  Google Scholar 

  14. H. Zhang, X. Li, J. Ding, H. Xu, X. Dai, Z. Hou, K. Zhang, K. Sun, and W. Sun, Int. J. Pharm., 441, 261 (2013).

    Article  CAS  PubMed  Google Scholar 

  15. S. Caldeira de Araújo Lopes, M. Vinícius Melo Novais, C. Salviano Teixeira, K. Honorato-Sampaio, M. Tadeu Pereira, L.A. Ferreira, F. C. Braga, and M. C. Oliveira, Biomed. Res. Int., 2013, 467147 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. L. Brannon-Peppas and J. O. Blanchette, Adv. Drug Deliv. Rev., 56, 1649 (2004).

    Article  CAS  PubMed  Google Scholar 

  17. T. A. Elbayoumi and V. P. Torchilin, Int. J. Pharm., 357, 272 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. G. Yang, T. Yang, W. Zhang, M. Lu, X. Ma, and G. Xiang, J. Agric. Food Chem., 62, 2207 (2014).

    Article  CAS  PubMed  Google Scholar 

  19. Y. Gao, Z. Li, X. Xie, C. Wang, J. You, F. Mo, B. Jin, J. Chen, J. Shao, H. Chen, and L. Jia, Eur. J. Pharm. Sci., 70, 55 (2015).

    Article  CAS  PubMed  Google Scholar 

  20. R. Sridhar and S. Ramakrishna, Biomatter, 3, e24281 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  21. D. N. Nguyen, C. Clasen, and G. V. den Mooter, J. Pharm. Sci., 105, 2601 (2016).

    Article  CAS  PubMed  Google Scholar 

  22. J. Ai, Y. Xu, D. Li, Z. Liu, and E. Wang, Talanta, 101, 32 (2012).

    Article  CAS  PubMed  Google Scholar 

  23. Z. Zhang, J. Jia, Y. Lai, Y. Ma, J. Weng, and L. Sun, Bioorg. Med. Chem., 18, 5528 (2010).

    Article  CAS  PubMed  Google Scholar 

  24. H. Song, C. Su, W. Cui, B. Zhu, L. Liu, Z. Chen, and L. Zhao, Biomed. Res. Int., 2013, 723158 (2013).

    PubMed  PubMed Central  Google Scholar 

  25. F. Liu, D. Deng, X. Chen, Z. Qian, S. Achilefu, and Y. Gu, Mol. Imaging Biol., 12, 595 (2010).

    Article  PubMed  Google Scholar 

  26. Y. Kashiwada, T. Nagao, A. Hashimoto, Y. Ikeshiro, H. Okabe, L. M. Cosentino, and K. H. Lee, J. Nat. Prod., 63, 1619 (2000).

    Article  CAS  PubMed  Google Scholar 

  27. J. J. Pillai, A. K. T. Thulasidasan, R. J. Anto, N. C. Devika, N. Ashwanikumar, and G. V. Kumar, RSC Adv., 5, 25518 (2015).

    Article  CAS  Google Scholar 

  28. N. Bock, M. A. Woodruff, R. Steck, D. W. Hutmacher, B. L. Farrugia, and T. R. Dargaville, Macromol. Biosci., 14, 202 (2014).

    Article  CAS  PubMed  Google Scholar 

  29. A. Jaworek, A. Krupa, M. Lackowski, A.T. Sobczyk, T. Czech, S. Ramakrishna, S. Sundarrajan, and D. Pliszka, Fibers Text. East. Eur., 17, 77 (2009).

    CAS  Google Scholar 

  30. D. H. Paik and S. W. Choi, Macromol. Rapid Commun., 35, 1033 (2014).

    Article  CAS  PubMed  Google Scholar 

  31. A. M. Alkilany and C. J. Murphy, J. Nanopart. Res., 12, 2313(2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. T. K. Ryu, G. J. Lee, C. K. Rhee, and S. W. Choi, Macromol. Biosci., 15, 1469 (2015).

    Article  CAS  PubMed  Google Scholar 

  33. H. B. Raju, Y. Hu, A. Vedula, S. R. Dubovy, and J. L. Goldberg, PLoS One 6, e17452 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. J. Li, W. J. Guo, and Q. Y. Yang, World J. Gastroenterol., 8, 493 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Sung-Wook Choi.

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Acknowledgments: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF- 2015R1A4A1042350 and NRF- 2017R1A2B4008093), a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry Health & Welfare, Republic of Korea (grant number: HI17C0886), and the Catholic University of Korea, Research Fund, 2017.

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Ahn, G.Y., Paik, DH., Jeong, KY. et al. Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy. Macromol. Res. 26, 573–576 (2018). https://doi.org/10.1007/s13233-018-6089-x

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  • DOI: https://doi.org/10.1007/s13233-018-6089-x

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