Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report

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  1. 1.

    Henter J-I, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. J Clin Oncol. 2007;27(1):4169.

    Google Scholar 

  2. 2.

    Larroche C. Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment. Jt Bone Spine. 2012;79(4):356–61.

    Article  CAS  Google Scholar 

  3. 3.

    Henter J, Elinder G, Soder O, Ost AKE. Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis. Acta Pizdiatr Scand. 1991;80(2):428–35.

    Article  CAS  Google Scholar 

  4. 4.

    Esumi N, Imashuku S. Hyperferritinemia in malignant histiocytosis, virus-associated hemophagocytic syndrome and familial erythrophagocytic lymphohistiocytosis. Acta Paediatr Scand. 1989;5:268–70.

    Article  CAS  Google Scholar 

  5. 5.

    Bergsten E, Horne AC, Aricó M, Astigarraga I, Egeler RM, Filipovich AH, et al. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study. Blood. 2017;130(25):2728–38.

    Article  CAS  Google Scholar 

  6. 6.

    Niece JA, Rogers ZR, Ahmad N, Langevin A-M, MaClain KL. Hemophagocytic lymphohistiocytosis in texas: observations on ethnicity and race. J Clin Oncol [Internet]. 2010;27(1):4169.

    Google Scholar 

  7. 7.

    Trottestam H, Horne AC, Aricò M, Egeler RM, Filipovich AH, Gadner H, et al. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol. Blood. 2011;118(17):4577–84.

    Article  CAS  Google Scholar 

  8. 8.

    Ferreri AJM, Dognini GP, Campo E, Willemze R, Seymour JF, Bairey O, et al. Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions. Haematologica. 2007;92(4):486–92.

    Article  Google Scholar 

  9. 9.

    Henter J, Elinder G. Haemophagocytic lymphohistiocytosis: an inherited primary form and a reactive secondary form. Br J Haematol. 1995;91:774–5.

    Article  CAS  Google Scholar 

  10. 10.

    Clementi R, Emmi L, Maccario R, Liotta F, Moretta L, Danesino C, et al. Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations. Blood. 2002;100(6):2266–7.

    Article  CAS  Google Scholar 

  11. 11.

    Henter JI, Aricò M, Elinder G, Imashuku S, Janka G. Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12(2):417–33.

    Article  CAS  Google Scholar 

  12. 12.

    Janka GE. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr. 1983;140(3):221–30.

    Article  CAS  Google Scholar 

  13. 13.

    Jayawardena L, McNamara E. Diagnosis and management of pregnancies complicated by Haemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) syndrome in the tertiary setting. Intern Med J. 2019.

    Article  Google Scholar 

  14. 14.

    Herath RP, Siriwardana SR, Ekanayake CD, Abeysekara V, Kodithuwakku SUA, Herath HP. Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: a cross sectional analytical study. PLoS ONE. 2019;14(4):1–15.

    Article  CAS  Google Scholar 

  15. 15.

    van Kester MS, Langeveld TJC, Bouwsma H, van Rees JB, Holman ER, Teng YKO, et al. A breathtaking DRESS due to amoxicillin–clavulanate presenting as polymorphic eruption of the pregnancy. J Eur Acad Dermatol Venereol. 2018;32(12):e436–7.

    Article  Google Scholar 

  16. 16.

    He M, Jia J, Zhang J, Beejadhursing R, Mwamaka Sharifu L, Yu J, et al. Pregnancy-associated hemophagocytic lymphohistiocytosis secondary to NK/T cells lymphoma. Medicine (United States). 2017;96(47):e8628.

    Google Scholar 

  17. 17.

    Shukla A, Kaur A, Hira HS. Pregnancy induced haemophagocytic syndrome. J Obstet Gynecol India. 2013;63(3):203–5.

    Article  Google Scholar 

  18. 18.

    Sarkissian S, Khan Y, Farrell D, Constable D, Brem E. Hemophagocytic lymphohistiocytosis in the setting of HELLP syndrome. Clin Case Rep. 2018;6(12):2466–70.

    Article  Google Scholar 

  19. 19.

    Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7(1):467–74.

    PubMed  PubMed Central  Google Scholar 

  20. 20.

    Williams Z, Zepf D, Longtine J, Anchan R, Broadman B, Missmer SA, et al. Foreign fetal cells persist in the maternal circulation. Fertil Steril. 2009;91(6):2593–5.

    Article  Google Scholar 

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Correspondence to Luis A. Sánchez-Ato.

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This study is exempted from ethical approval by ethics committee of Hospital Nacional Edgardo Rebagliati Martins.

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Luis A. Sánchez-Ato ia an assistant professor, Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; Flavia A. Cuestas‑Quiroz ia an assistant professor Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; Carla Agurto‑Saldana is a Gynecologist, Departamento de Obstetricia y Ginecología, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru; David Estela‑Ayamamani is a Gynecologist, Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru and Departamento de Obstetricia y Ginecología, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.

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Sánchez-Ato, L.A., Cuestas-Quiroz, F.A., Agurto-Saldaña, C. et al. Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report. J Obstet Gynecol India 70, 390–392 (2020).

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