Abstract
Objective
Granulosa cell tumor (GCT) is a rare entity of ovarian malignancies. Juvenile GCT is considered a malignant tumor with an indolent course and tendency toward late recurrence. However, the association of this tumor and multiple enchondromas has been reported.
Case Presentation
A 17-year-old female with abnormal uterine bleeding was referred to our center. Ultrasonographic evaluation revealed a mass with origin in right ovary. Patient was worked up to undergo salpingo-oophorectomy, she felt a dull pain in her left lower limb. X-ray imaging was indicative for Ollier’s disease at the distal part of femur and proximal part of tibia. Postoperative pathological review was compatible with juvenile granulosa tumor of the right ovary.
Conclusion
This case was the first of its kind that ovarian tumor was contralateral to the side involved by enchondromatosis.
References
Kottarathil VD, Antony MA, Nair IR, et al. Recent advances in granulosa cell tumor ovary: a review. Indian J Surg Oncol. 2013;4(1):37–47.
Park J-Y, Jin KL, Kim DY, et al. Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. Gynecol Oncol. 2012;125(1):80–6.
Colombo N, Parma G, Zanagnolo V, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;25(20):2944–51.
Brown J, Sood AK, Deavers MT, et al. Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? Gynecol Oncol. 2009;113(1):86–90.
Yu S, Zhou X, Hou B, et al. Metastasis of the liver with a granulosa cell tumor of the ovary: a case report. Oncol Lett. 2015;9(2):816–8.
Thirumala SD, Putti TC, Medalie NS, et al. Skeletal metastases from a granulosa-cell tumor of the ovary: report of a case diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 1998;19(5):375–7.
Piura B, Nemet D, Yanai‐Inbar I, et al. Granulosa cell tumor of the ovary: a study of 18 cases. J Surg Oncol. 1994;55(2):71–7.
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treat Rev. 2008;34(1):1–12.
Tanaka Y, Sasaki Y, Nishihira H, et al. Ovarian juvenile granulosa cell tumor associated with Maffucci’s syndrome. Am J Clin Pathol. 1992;97(4):523–7.
Grenet P, Le GC, Badoual J, et al. Dyschondroplasia and ovarian tumor. Ann Pediatr (Paris). 1972;19(11):759–64.
Lewis RJ, Ketcham AS. Maffucci’s syndrome: functional and neoplastic significance case report and review of the literature. JBJS. 1973;55(7):1465–79.
Vaz RM, Turner C. Ollier disease (enchondromatosis) associated with ovarian juvenile granulosa cell tumor and precocious pseudopuberty. J Pediatr. 1986;108(6):945–7.
Asirvatham R, Rooney RJ, Watts HG. Ollier’s disease with secondary chondrosarcoma associated with ovarian tumour. Int Orthop. 1991;15(4):393–5.
Gell J, Stannard MW, Ramnani DM, et al. Juvenile Granulosa cell tumor in a 13-year-old girl with enchondromatosis (Oilier’s Disease): a case report. J Pediatr Adolesc Gynecol. 1998;11(3):147–50.
Rietveld L, Nieboer TE, Kluivers KB, et al. First case of juvenile granulosa cell tumor in an adult with Ollier disease. Int J Gynecol Pathol. 2009;28(5):464–7.
Hachi H, Othmany A, Douayri A, et al. Association d’une tumeur ovarienne de la granulosa juvénile à un syndrome de Maffucci. Gynécol Obstét Fertil. 2002;30(9):692–5.
Tamimi HK, Bolen JW. Enchondromatosis (Ollier’s disease) and ovarian juvenile granulosa cell tumor. A case report and review of the literature. Cancer. 1984;53(7):1605–8.
Pounder DJ, Iyer PV, Davy MLJ. Bilateral juvenile granulosa cell tumours associated with skeletal enchondromas. Aust N Z J Obstet Gynaecol. 1985;25(2):123–6.
Prat J, Oncology FCOG. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynecol Obstet. 2014;124(1):1–5.
Burgetova A, Matejovsky Z, Zikan M, et al. The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). Taiwan J Obstet Gynecol. 2017;56(2):253–7.
Sugiyama M, Kohmoto Y, Miyoshi T, et al. In vivo and in vitro steroid bio-synthesis by ovarian juvenile granulosa cell tumor of a girl with Ollier’s disease. Acta Gynaecol Obstet Jpn. 1983;35(2):2185.
Velasco-Oses A, Alonso‐Alvaro A, Blanco‐Pozo A, et al. Ollier’s disease associated with ovarian juvenile granulosa cell tumor. Cancer. 1988;62(1):222–5.
Le CG, Bouvier R, Chappuis JP, et al. Ollier’s disease and juvenile ovarian granulosa tumor. Arch Fr Pediat. 1991;48(2):115–8.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All authors declare that there is no conflict of interest to disclose.
Human Participants and/or Animals
All parts of Declaration of Helsinki have been applied.
Informed Consent
The patient gave us written consent of her inclusion in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Amirmohsen Jalaeefar, Assistant Professor at Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; Mohammad Shirkhoda, Assistant Professor at Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; Amirsina Sharifi, Research Associate at Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Mohsen Sfandbod, Assistant Professor at Department of Hematology and Oncology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Rights and permissions
About this article
Cite this article
Jalaeefar, A., Shirkhoda, M., Sharifi, A. et al. Granulosa Cell Tumor of the Ovary Accompanying with Ollier’s Disease: First Case of Contralateral Presentations. J Obstet Gynecol India 70, 81–85 (2020). https://doi.org/10.1007/s13224-019-01243-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13224-019-01243-1