3 Biotech

, 8:156 | Cite as

Antimicrobial and anticancer activity of AgNPs coated with Alphonsea sclerocarpa extract

  • Suman Joshi D S Doddapaneni
  • Chander Amgoth
  • Arunasree M Kalle
  • Surya Narayana Suryadevara
  • Krishna Satya Alapati
Original Article


The synthesis and characterization of an aggregate of AgNPs coated with plant extract (PE) from Alphonsea sclerocarpa and its significant antimicrobial activity and inhibition on K562 (blood cancer) cells have been appended in the article. Synthesis of aggregate [(AgNPs)-(PE)] has been followed by a facile eco-friendly approach without using any harmful chemicals. The morphology of an aggregate [(AgNPs)-(PE)] was confirmed by TEM and SEM microscopic characterizations. Properties like solid state, the presence of functional groups, and elemental composition have been characterized through the XRD, FTIR, and EDAX. The biocompatibility of synthesized aggregate of [(AgNPs)-(PE)] was confirmed by the MTT assay. An in vitro cell (HEK293)-based studies were performed for the biocompatibility tests and it is found that the aggregate [(AgNPs)-(PE)] is not harmful to normal/healthy cells. Even though A. sclerocarpa show the antimicrobial (antibacterial and antifungal) activity, it has been further enhanced with the developed aggregate of [(AgNPs)-(PE)]. Furthermore, it has been extended to examine the cellular inhibition on K562 cells and obtained > 75% cell inhibition for 24 h treated cells.


[(AgNPs)-PE)] Silver nanoparticles Antimicrobial activity Cell inhibition 



The authors would like to acknowledge DST-FIST, Department of Physics, Acharya Nagarjuna University for providing IR facility, University of Hyderabad, for providing SEM with EDAX and XRD facility.

Compliance with ethical standards

Conflict of interest

Both the first and second authors have equal contribution to the paper.

Supplementary material

13205_2018_1155_MOESM1_ESM.docx (6.1 mb)
Supplementary material 1 (DOCX 6282 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Suman Joshi D S Doddapaneni
    • 1
  • Chander Amgoth
    • 2
  • Arunasree M Kalle
    • 3
  • Surya Narayana Suryadevara
    • 1
  • Krishna Satya Alapati
    • 1
  1. 1.Department of BiotechnologyAcharya Nagarjuna UniversityGunturIndia
  2. 2.School of Engineering Sciences and TechnologyUniversity of HyderabadHyderabadIndia
  3. 3.Department of Animal Sciences, School of Life sciencesUniversity of HyderabadHyderabadIndia

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