Applied Nanoscience

, Volume 8, Issue 3, pp 395–405 | Cite as

Reduced graphene oxide aerogel networks with soft interfacial template for applications in bone tissue regeneration

  • S. Asha
  • A. Nimrodh Ananth
  • Sujin P. Jose
  • M. A. Jothi Rajan
Original Article


Reduced Graphene Oxide aerogels (A-RGO), functionalized with chitosan, were found to induce and/or accelerate the mineralization of hydroxyapatite. The functionalized chitosan acts as a soft interfacial template on the surface of A-RGO assisting the growth of hydroxyapatite particles. The mineralization on these soft aerogel networks was performed by soaking the aerogels in simulated body fluid, relative to time. Polymer-induced mineralization exhibited an ordered arrangement of hydroxyapatite particles on reduced graphene oxide aerogel networks with a higher crystalline index (IC) of 1.7, which mimics the natural bone formation indicating the importance of the polymeric interfacial template. These mineralized aerogels which mimic the structure and composition of natural bone exhibit relatively higher rate of cell proliferation, osteogenic differentiation and osteoid matrix formation proving it to be a potential scaffold for bone tissue regeneration.


Aerogel Graphene oxide Hydroxyapatite Chitosan Soft interfacial template 



The author S.A acknowledge the Department of Science and Technology, New-Delhi for providing financial support through the award of Women Scientist Scheme A (Grant No: SR/WOS-A/PS-46/2012(G)).

Supplementary material

13204_2018_803_MOESM1_ESM.docx (549 kb)
Supplementary material 1 (DOCX 549 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Bio-Nano Laboratory, PG and Research Department of PhysicsArul Anandar CollegeMaduraiIndia
  2. 2.Chemical Engineering and Process Development DivisionCSIR-National Chemical LaboratoryPuneIndia
  3. 3.Department of Computational Physics, School of PhysicsMadurai Kamaraj UniversityMaduraiIndia

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