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Essentials for Pathological Evaluation of Peritoneal Surface Malignancies and Synoptic Reporting of Cytoreductive Surgery Specimens—A review and evidence-based guide

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Abstract

Peritoneal surface oncology has emerged as a subspecialty of surgical oncology, with the growing popularity of surgical treatment of peritoneal metastases comprising of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Pathological evaluation plays a key role in multidisciplinary management but there are still many areas where there are no guidelines or consensus on reporting. Some tumors presenting to a peritoneal surface oncology unit are rare and pathologists my not be familiar with diagnosing and classifying those. In this manuscript, we have reviewed the evidence regarding various aspects of histopathological evaluation of peritoneal tumors. It includes establishing a diagnosis, appropriate classification and staging of common and rare tumors and evaluation of pathological response to chemotherapy. In many instances, the information captured is of prognostic value alone with no direct therapeutic implications. But proper capturing of such information is vital for generating evidence that will guide future treatment trends and research. There are no guidelines/data set for reporting cytoreductive surgery specimens. Based on the authors’ experience, a format for handling/grossing and synoptic reporting of these specimens is provided.

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References

  1. Passot G, Vaudoyer D, Villeneuve L et al (2016) What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: a 25-year experience with 1,125 procedures. J Surg Oncol 113:796–803

    Article  PubMed  Google Scholar 

  2. Levine EA, Stewart JH, Shen P, Russell GB, Loggie BL, Votanopoulos KI (2014) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1,000 patients. J Am Coll Surg 218(4):573–585. https://doi.org/10.1016/j.jamcollsurg.2013.12.013

    Article  PubMed  Google Scholar 

  3. Bhatt A, Mehta SS, Zaveri S, Rajan F, Ray M, Sethna K, Katdare N, Patel MD, Kammar P, Prabhu R, Sinukumar S, Mishra S, Rangarajan B, Rangole A, Damodaran D, Penumadu P, Ganesh M, Peedicayil A, Raj H, Seshadri R (2018) Treading the beaten path with old and new obstacles: a report from the Indian HIPEC registry. Int J Hyperth. https://doi.org/10.1080/02656736.2018.1503345

    Article  PubMed  Google Scholar 

  4. Sugarbaker PH (1995) Peritonectomy procedures. Ann Surg 221(1):29–42. https://doi.org/10.1097/00000658-199501000-00004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Neumeister VM, Anagnostou V, Siddiqui S et al (2012) Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. J Natl Cancer Inst 104:1815–1824

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Portier BP, Wang Z, Downs-Kelly E et al (2013) Delay to formalin fixation ‘cold ischemia time’: effect on ERBB2 detection by in-situ hybridization and immunohistochemistry. Mod Pathol 26:1–9

    Article  CAS  PubMed  Google Scholar 

  7. Engel KB, Moore HM (2011) Effects of pre-analytical variables on the detection of proteins by immunohistochemistry in formalin-fixed, paraffin-embedded tissue. Arch Pathol Lab Med 135:537–543

    PubMed  Google Scholar 

  8. Arber DA (2002) Effect of prolonged formalin fixation on the immunohistochemical reactivity of breast markers. Appl Immunohistochem Mol Morphol 10:183–186

    PubMed  Google Scholar 

  9. Babic A, Loftin IR, Stanislaw S et al (2010) The impact of pre-analytical processing on staining quality for H&E, dual hapten, dual color in situ hybridization and fluorescent in situ hybridization assays. Methods 52:287–300

    Article  CAS  PubMed  Google Scholar 

  10. Chafin D, Theiss A, Roberts E et al (2013) Rapid two-temperature formalin fixation. PLoS One 8:e54138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Kerr KM, Bubendorf L, Edelman MJ et al (2014) Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer. Ann Oncol 25:1681–1690

    Article  CAS  PubMed  Google Scholar 

  12. McCluggage WG, Judge MJ, Clarke BA, Davidson B, Gilks CB, Hollema H, Ledermann JA, Matias-Guiu X, Mikami Y, Stewart CJ, Vang R, Hirschowitz L (2015) International collaboration on cancer reporting. Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR). Mod Pathol 28(8):1101–1122. https://doi.org/10.1038/modpathol.2015.77

    Article  PubMed  Google Scholar 

  13. Doig T, Monaghan H (2006) Sampling the omentum in ovarian neoplasia: when one block is enough. Int J Gynecol Cancer 16:36–40

    Article  CAS  PubMed  Google Scholar 

  14. Usubütün A, Ozseker HS, Himmetoglu C et al (2007) Omentectomy for gynecologic cancer: how much sampling is adequate for microscopic examination? Arch Pathol Lab Med 131:1578–1581

    PubMed  Google Scholar 

  15. Cotte E, Peyrat P, Piaton E, Chapuis F, Rivoire M, Glehen O, Arvieux C, Mabrut JY, Chipponi J, Gilly FN, EVOCAPE group (2013) Lack of prognostic significance of conventional peritoneal cytology in colorectal and gastric cancers: results of EVOCAPE 2 multicentre prospective study. Eur J Surg Oncol 39(7):707–714. https://doi.org/10.1016/j.ejso.2013.03.021

    Article  CAS  PubMed  Google Scholar 

  16. Hayes N, Wayman J, Wadehra V et al (1999) Peritoneal cytology in the surgical evaluation of gastric carcinoma. Br J Cancer 79:520–524

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Pande R, Sunga A, Levea C, Wilding GE, Bshara W, Reid M, Fakih MG (2008) Significance of signet-ring cells in patients with colorectal cancer. Dis Colon Rectum 51:50–55

    Article  PubMed  Google Scholar 

  18. Solass W, Sempoux C, Carr NJ, Detlefsen S, Bibeau F (2016) Peritoneal sampling and histological assessment of therapeutic response in peritoneal metastasis: proposal of the Peritoneal Regression Grading Score (PRGS). Pleura Perit 1:99–107

    Google Scholar 

  19. Bibeau F, Gil H, Castan F et al (2013) Comment on “Histopathologic evaluation of liver metastases from colorectal cancer in patients treated with FOLFOXIRI plus bevacizumab”. Br J Cancer 109:3127–3129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Chang HHL, Leeper WR, Chan G, Quan D, Driman DK (2012) Infarct-like necrosis: a distinct form of necrosis seen in colorectal carcinoma liver metastases treated with perioperative chemotherapy. Am J Surg Pathol 36:570–576

    Article  PubMed  Google Scholar 

  21. Becker K, Mueller JD, Schulmacher C, Ott K, Fink U, Busch R et al (2003) Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy. Cancer 98:1521–1530

    Article  PubMed  Google Scholar 

  22. Chirieac LR, Swisher SG, Correa AM et al (2005) Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma. Clin Cancer Res 11:2229–2236

    Article  CAS  PubMed  Google Scholar 

  23. Shia J, McManus M, Guillem JG et al (2011) Significance of acellular mucin pools in rectal carcinoma after neoadjuvant chemoradiotherapy. Am J Surg Pathol 35:127–134

    Article  PubMed  Google Scholar 

  24. Lim S-B, Hong S-M, Yu CS et al (2013) Prevalence and clinical significance of acellular mucin in locally advanced rectal cancer patients showing pathologic complete response to preoperative chemoradiotherapy. Am J Surg Pathol 37:47–52

    Article  PubMed  Google Scholar 

  25. Passot G, You B, Boschetti G, Fontaine J, Isaac S, Decullier E, Maurice C, Vaudoyer D, Gilly FN, Cotte E, Glehen O (2014) Pathological response to neoadjuvant chemotherapy: a new prognosis tool for the curative management of peritoneal colorectal carcinomatosis. Ann Surg Oncol 21(8):2608–2614. https://doi.org/10.1245/s10434-014-3647-0

    Article  PubMed  Google Scholar 

  26. Rubbia-Brandt L et al (2007) Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. Ann Oncol 18(2):299–304

    Article  CAS  PubMed  Google Scholar 

  27. Blazer DG 3rd et al (2008) Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol 26(33):5344–5351

    Article  PubMed  Google Scholar 

  28. Yonemura Y, Canbay E, Ishibashi H (2013) Prognostic factors of peritoneal metastases from colorectal cancer following cytoreductive surgery and perioperative chemotherapy. Sci World J 2013:978394. https://doi.org/10.1155/2013/978394

    Article  Google Scholar 

  29. Chang HH, Leeper WR, Chan G, Quan D, Driman DK (2012) Infarct-like necrosis: a distinct form of necrosis seen in colorectal carcinoma liver metastases treated with perioperative chemotherapy. Am J Surg Pathol 36(4):570–576. https://doi.org/10.1097/PAS.0b013e31824057e7

    Article  PubMed  Google Scholar 

  30. McCluggage WG, Wilkinson N (2005) Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features. Histopathology 47:231–247

    Article  CAS  PubMed  Google Scholar 

  31. McCluggage WG (2000) Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol 53:558–560

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. McCluggage WG (2002) Recent advances in immunohistochemistry in gynaecological pathology. Histopathology 46:309–326

    Article  Google Scholar 

  33. McCluggage WG, Young RH (2005) Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol 22:3–32

    Article  PubMed  Google Scholar 

  34. Vang R, Gown AM, Barry TS et al (2006) Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 30:1130–1139

    Article  PubMed  Google Scholar 

  35. Strickland S, Parra-Herran C (2016) Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special AT-rich sequence-binding protein 2 in their distinction from primary mucinous tumours. Histopathology 68:977–987

    Article  PubMed  Google Scholar 

  36. Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT (2016) SATB expression distinguishes ovarian metastases of colorectal and appendiceal origin from primary ovarian tumors of mucinous or endometrioid type. Am J Surg Pathol 40:419–432

    Article  PubMed  Google Scholar 

  37. Leen SL, Singh N (2012) Pathology of primary and metastatic mucinous ovarian neoplasms. J Clin Pathol 65:591–595

    Article  PubMed  Google Scholar 

  38. Carr NJ, Bibeau F, Bradley RF, Dartigues P (2017 Dec) The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. Histopathology 71(6):847e58. https://doi.org/10.1111/his.13324

    Article  Google Scholar 

  39. Stewart CJ, Ardakani NM, Doherty DA, Young RH (2014) An evaluation of the morphologic features of low-grade mucinous neoplasms of the appendix metastatic in the ovary and a comparison with primary ovarian mucinous tumors. Int J Gynecol Pathol 33:1–10

    Article  PubMed  Google Scholar 

  40. Nonaka D, Chiriboga L, Soslow RA (2008) Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol 32:1566–1571

    Article  PubMed  Google Scholar 

  41. Tornos C, Soslow R, Chen S et al (2005) Expression of WT1, CA125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol 29:1482–1489

    Article  PubMed  Google Scholar 

  42. Liu H, Shi J, Wilkerson ML et al (2012) Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol 138:57–64

    Article  PubMed  Google Scholar 

  43. Bhargava R, Beriwal S, Dabbs DJ (2007) Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 127:103–113

    Article  CAS  PubMed  Google Scholar 

  44. Ronnett BM, Yemelyanova AV, Vang R et al (2008) Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumours and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 32:1835–1853

    Article  PubMed  Google Scholar 

  45. Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A et al (2015) Chemotherapy response score: development and validation of a system to quantify histopathologic response to neoadjuvant chemotherapy in tubo-ovarian high-grade serous carcinoma. J Clin Oncol 33(22):2457–2463. https://doi.org/10.1200/JCO.2014.60.5212

    Article  CAS  PubMed  Google Scholar 

  46. Le T, Williams K, Senterman M et al (2007) Histopathologic assessment of chemotherapy effects in epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and delayed primary surgical debulking. Gynecol Oncol 106:160–163

    Article  CAS  PubMed  Google Scholar 

  47. Muraji M, Sudo T, Iwasaki S et al (2013) Histopathology predicts clinical outcome in advanced epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and debulking surgery. Gynecol Oncol 131:531–534

    Article  PubMed  Google Scholar 

  48. Bhatt A, Passot G, Glehen O Pseudomyxoma peritonei arising from epithelial appendiceal tumours. Bhatt A (ed) Management of peritoneal metastases- Cytoreductive surgery, HIPEC and beyond. https://doi.org/10.1007/978-981-10-7053-2_13

    Google Scholar 

  49. Panarelli N, Yantiss R (2011) Mucinous neoplasms of the appendix and peritoneum. Arch Pathol Lab Med 135(10):1261–1268. https://doi.org/10.5858/arpa.2011-0034-RA

    Article  PubMed  Google Scholar 

  50. Carr NJ, Sobin LH (2010) Tumours of the appendix. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO Classification of Tumours of the Digestive System, vol 3, 4th edn. IARC Press, Lyon, pp 122–125

    Google Scholar 

  51. Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH (2003) Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases. Am J Surg Pathol 27(8):1089–1103

    Article  PubMed  Google Scholar 

  52. Panarelli NC, Yantiss RK (2011) Mucinous neoplasms of the appendix and peritoneum. Arch Pathol Lab Med 135(10):1261–1268. https://doi.org/10.5858/arpa.2011-0034-ra

    Article  PubMed  Google Scholar 

  53. Ronnett BM et al (1995) Disseminated peritoneal adenomucinosis and peritoneal mucinous adenocarcinoma: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis and relationship to pseudomyxoma peritonei. Am J Surg Pathol 19(12):1390–1408. https://doi.org/10.1097/00000478-199512000-00006

    Article  CAS  PubMed  Google Scholar 

  54. Bradley RF, Stewart JH, Russell GB, Levine EA, Geisinger KR (2006) Pseudomyxoma peritonei of appendiceal origin: a clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review. Am J Surg Pathol 30(5):551–559

    Article  PubMed  Google Scholar 

  55. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds) (2010) AJCC cancer staging manual, 7th edn. Springer, New York, NY, pp 133–141.

  56. Carr NJ et al (2012) Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases. J Clin Pathol 65(10):919–923. https://doi.org/10.1136/jclinpath-2012-200843

    Article  PubMed  Google Scholar 

  57. Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ (2016) A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: the results of the peritoneal surface oncology group international (PSOGI) modified Delphi process. Am J Surg Pathol 40(1):14–26. https://doi.org/10.1097/PAS.0000000000000535

    Article  PubMed  Google Scholar 

  58. Connor SJ, Hanna GB, Frizelle FA (1998) Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7,970 appendectomies. Dis Colon Rectum 41(1):75

    Article  CAS  PubMed  Google Scholar 

  59. College of American Pathologists. Protocol for the examination of specimens from patients with carcinoma of the appendix. October 2013. Available at: http://www.cap.org/apps/cap.portal?_nfpb. Accessed 27 Oct 2018

  60. Brierley JD, Gospodarowicz MK, Wittekind C (2017) UICC (Union for International Cancer Control) TNM Classification of Malignant Tumours, 8th edn. John Wiley & Sons, Oxford

    Google Scholar 

  61. Honoré C, Caruso F, Dartigues P, Benhaim L, Chirica M, Goéré D, Elias D (2015) Strategies for preventing pseudomyxoma peritonei after resection of a mucinous neoplasm of the appendix. Anticancer Res 35(9):4943–4947

    PubMed  Google Scholar 

  62. McDonald JR, O’Dwyer ST, Rout S, Chakrabarty B, Sikand K, Fulford PE, Wilson MS, Renehan AG (2012) Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms. Br J Surg 99(7):987–992. https://doi.org/10.1002/bjs.8739

    Article  CAS  PubMed  Google Scholar 

  63. Guaglio M, Sinukumar S, Kusamura S, Milione M, Pietrantonio F, Battaglia L, Guadagni S, Baratti D, Deraco M (2018) Clinical surveillance after macroscopically complete surgery for low-grade appendiceal mucinous neoplasms (LAMN) with or without limited peritoneal spread: long-term results in a prospective series. Ann Surg Oncol 25(4):878–884. https://doi.org/10.1245/s10434-017-6305-5

    Article  PubMed  Google Scholar 

  64. Sammartino P, Biacchi D, Cornali T, Cardi M, Accarpio F, Impagnatiello A, Sollazzo BM, Di Giorgio A (2016) Proactive management for gastric, colorectal and appendiceal malignancies: preventing peritoneal metastases with hyperthermic intraperitoneal chemotherapy (HIPEC). Indian J Surg Oncol 7(2):215–224. https://doi.org/10.1007/s13193-016-0497-1

    Article  PubMed  PubMed Central  Google Scholar 

  65. Misdraji J, Lauwers GY, Irving JA, Batts KP, Young RH (2014) Appendiceal or cecal endometriosis with intestinal metaplasia: a potential mimic of appendiceal mucinous neoplasms. Am J Surg Pathol 38:698–705

    Article  PubMed  Google Scholar 

  66. Mitchell A, Dube P, Sideris L (2014) Dysplastic intestinal-type metaplasia of appendiceal endometriosis: a mimic of low grade appendiceal mucinous neoplasm. Diagn Pathol 9:39

    Article  PubMed  PubMed Central  Google Scholar 

  67. Sirintrapun SJ, Blackham AU, Russell G et al (2014) Significance of signet ring cells in high-grade mucinous adenocarcinoma of the peritoneum from appendiceal origin. Hum Pathol 45:1597–1604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Davison JM, Choudry HA, Pingpank JF et al (2014) Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade. Mod Pathol 27:1521–1539

    Article  PubMed  Google Scholar 

  69. Shetty S, Natarajan B, Thomas P, Govindarajan V, Sharma P, Loggie B (2013) Proposed classification of pseudomyxoma peritonei: influence of signet ring cells on survival. Am Surg 79:1171–1176

    PubMed  Google Scholar 

  70. Taggart MW, Galbincea J, Mansfield PF et al (2013) High-level microsatellite instability in appendiceal carcinomas. Am J Surg Pathol 37:1192–1200

    Article  PubMed  PubMed Central  Google Scholar 

  71. Bhatt A, Mishra S, Prabhu R, Ramaswamy V, George A, Bhandare S, Shah M, Mehta S (2018) Can low grade PMP be divided into prognostically distinct subgroups based on histological features? A retrospective study and the importance of using the appropriate classification. Eur J Surg Oncol 44(7):1105–1111. https://doi.org/10.1016/j.ejso.2018.03.032

    Article  PubMed  Google Scholar 

  72. Baratti D, Kusamura S, Milione M, Bruno F, Guaglio M, Deraco M (2018) Validation of the recent PSOGI pathological classification of pseudomyxoma peritonei—a single center series of 265 patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol 25(2):404–413. https://doi.org/10.1245/s10434-017-6252-1

    Article  PubMed  Google Scholar 

  73. Choudry HA, Pai RK, Shuai Y, Ramalingam L, Jones HL, Pingpank JF, Ahrendt SS, Holtzman MP, Zureikat AH, Zeh HJ, Bartlett DL (2018) Impact of cellularity on oncologic outcomes following cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for pseudomyxoma peritonei. Ann Surg Oncol 25(1):76–82. https://doi.org/10.1245/s10434-017-6214-7

    Article  PubMed  Google Scholar 

  74. Mohamed F, Gething S, Haiba M, Brun EA, Sugarbaker PH et al (2004) Clinically aggressive pseudomyxoma peritonei: a variant of a histologically indolent process. J Surg Oncol 86(1):10e5

    Article  Google Scholar 

  75. Vang R, Gown AM, Zhao C et al (2007) Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 31:854–869

    Article  PubMed  Google Scholar 

  76. Choi YJ, Lee SH, Kim MS et al (2016) Whole-exome sequencing identified the genetic origin of a mucinous neoplasm in a mature cystic teratoma. Pathology 48:372–376

    Article  CAS  PubMed  Google Scholar 

  77. McKenney JK, Soslow RA, Longacre TA (2008) Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol 32:645–655

    Article  PubMed  Google Scholar 

  78. Lee KR, Scully RE (2000) Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'. Am J Surg Pathol 24:1447–1464

    Article  CAS  PubMed  Google Scholar 

  79. Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE (1984) Malignant urachal lesions. J Urol 131:1–8

    Article  CAS  PubMed  Google Scholar 

  80. Cappele O, Sibert L, Descargues J, Delmas V, Grise P (2001) A study of the anatomic features of the duct of the urachus. Surg Radiol Anat 23:229–235

    Article  CAS  PubMed  Google Scholar 

  81. Stenhouse G, McRae D, Pollock AM (2003) Urachal adenocarcinoma in situ with pseudomyxoma peritonei: a case report. J Clin Pathol 56:152–153

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. de Bree E, Witkamp A, Van de Vijver M, Zoetmulder F (2000) Unusual origins of pseudomyxoma peritonei. J Surg Oncol 75:270–274

    Article  PubMed  Google Scholar 

  83. Loggie BW, Fleming RA, Hosseinian AA (1997) Peritoneal carcinomatosis with urachal signet-cell adenocarcinoma. Urology 50:446–448

    Article  CAS  PubMed  Google Scholar 

  84. Santucci RA, True LD, Lange PH (1997) Is partial cystectomy the treatment of choice for mucinous adenocarcinoma of the urachus. Urology 49:536–540

    Article  CAS  PubMed  Google Scholar 

  85. Sugarbaker PH, Verghese M, Yan TD, Brun E (2008) Management of mucinous urachal neoplasm presenting as pseudomyxoma peritonei. Tumori 94(5):732–736

    Article  PubMed  Google Scholar 

  86. Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR (2018) Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 142(1):89–108. https://doi.org/10.5858/arpa.2017-0124-RA

    Article  CAS  PubMed  Google Scholar 

  87. Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women: a clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas, and localized fibrous tumors. Am J Surg Pathol 19(10):1124–1137

    Article  CAS  PubMed  Google Scholar 

  88. Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (eds) (2015) WHO. Classification of tumours of the lung, pleura, thymus and heart, vol 7, 4th edn. IARC Press, Lyon

    Google Scholar 

  89. Churg A, Allen T, Borczuk AC et al (2014) Well-differentiated papillary mesothelioma with invasive foci. Am J Surg Pathol 38(7):990–998

    Article  PubMed  Google Scholar 

  90. Churg A, Cagle PT, Roggli VL (eds) (2006) Tumors of the serosal membranes. Armed Registry of Pathology, and Washington, DC: Armed Forces Institute of Pathology, Silver Spring Atlas of Tumor Pathology; 4th series, fascicle

    Google Scholar 

  91. Kadota K, Suzuki K, Sima CS, Rusch VW, Adusumilli PS, Travis WD (2011) Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma. J Thorac Oncol 6(5):896–904

    Article  PubMed  Google Scholar 

  92. Ordonez NG (2012) Pleomorphic mesothelioma: report of 10 cases. Mod Pathol 25(7):1011–1022

    Article  PubMed  Google Scholar 

  93. Ordonez NG (2012) Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol 25(11):1481–1495

    Article  PubMed  Google Scholar 

  94. Kawai T, Hiroi S, Nakanishi K et al (2010) Lymphohistiocytoid mesothelioma of the pleura. Pathol Int 60(8):566–574

    Article  PubMed  Google Scholar 

  95. Travis WD (2010) Sarcomatoid neoplasms of the lung and pleura. Arch Pathol Lab Med 134(11):1645–1658

    PubMed  Google Scholar 

  96. Kiyozuka Y, Miyazaki H, Yoshizawa K et al (1999) An autopsy case of malignant mesothelioma with osseous and cartilaginous differentiation: bone morphogenetic protein-2 in mesothelial cells and its tumor. Dig Dis Sci 44(8):1626

    Article  CAS  PubMed  Google Scholar 

  97. Suen HC, Sudholt B, Anderson WM, Lakho MH, Daily BB (2002) Malignant mesothelioma with osseous differentiation. Ann Thorac Surg 73(2):665

    Article  PubMed  Google Scholar 

  98. Yousem SA, Hochholzer L (1987) Malignant mesotheliomas with osseous and cartilaginous differentiation. Arch Pathol Lab Med 111(1):62–66

    CAS  PubMed  Google Scholar 

  99. Borczuk AC, Taub RN, Hesdorffer M et al (2005) p16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesothelioma. Clin Cancer Res 11(9):3303–3308

    Article  CAS  PubMed  Google Scholar 

  100. Kannerstein M, Churg J (1977) Peritoneal mesothelioma. Hum Pathol 8(1):83–94

    Article  CAS  PubMed  Google Scholar 

  101. Comin CE, Saieva C, Messerini L (2007) h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol 31(8):1139–1148

    Article  PubMed  Google Scholar 

  102. Ordonez NG (2013) Value of PAX8, PAX2, claudin-4, and h-caldesmon immunostaining in distinguishing peritoneal epithelioid mesotheliomas from serous carcinomas. Mod Pathol 26(4):553–562

    Article  CAS  PubMed  Google Scholar 

  103. Comin CE, Saieva C, Messerini L (2007) h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol 31(8):1139–1148

    Article  PubMed  Google Scholar 

  104. Ordonez NG (2006) Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum: a review and update. Adv Anat Pathol 13(1):16–25

    Article  CAS  PubMed  Google Scholar 

  105. Barnetson RJ, Burnett RA, Downie I, Harper CM, Roberts F (2006) Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful. Am J Clin Pathol 125(1):67–76

    Article  CAS  PubMed  Google Scholar 

  106. Takeshima Y, Amatya VJ, Kushitani K, Inai K (2008) A useful antibody panel for differential diagnosis between peritoneal mesothelioma and ovarian serous carcinoma in Japanese cases. Am J Clin Pathol 130(5):771–779

    Article  CAS  PubMed  Google Scholar 

  107. Turaga KK, Deraco M, Alexander HR (2017) Current management strategies for peritoneal mesothelioma. Int J Hyperth 33(5):579–581. https://doi.org/10.1080/02656736.2017.1320591

    Article  Google Scholar 

  108. Kusamura S, Torres Mesa PA, Cabras A et al (2016) The role of Ki-67 and pre-cytoreduction parameters in selecting diffuse malignant peritoneal mesothelioma (DMPM) patients for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Ann Surg Oncol 23:1468–1473

    Article  PubMed  Google Scholar 

  109. Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH (2011) Peritoneal surface oncology group. A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer 117(9):1855–1863

    Article  PubMed  Google Scholar 

  110. Cook DS, Attanoos RL, Jalloh SS, Gibbs AR (2000) 'Mucin-positive' epithelial mesothelioma of the peritoneum: an unusual diagnostic pitfall. Histopathology 37:33–36

    Article  CAS  PubMed  Google Scholar 

  111. Facchetti F, Lonardi S, Gentili F et al (2007) Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions. Virchows Arch 451:669–680

    Article  CAS  PubMed  Google Scholar 

  112. Angarita FA, Hassan S, Cannell AJ, Dickson BC, Gladdy RA, Swallow CJ, Gupta A, Blackstein ME, McCart JA (2017) Clinical features and outcomes of 20 patients with abdominopelvic desmoplastic small round cell tumor. Eur J Surg Oncol 43(2):423–431

    Article  CAS  PubMed  Google Scholar 

  113. Chan AS, MacNeill S, Thorner P, Squire J, Zielenska M (1999) Variant EWS-WT1 chimeric product in the desmoplastic small round cell tumor. Pediatr Dev Pathol 2:188–192

    Article  CAS  PubMed  Google Scholar 

  114. Rodriguez E, Sreekantaiah C, Gerald W, Reuter VE, Motzer RJ, Chaganti RS (1993) A recurring translocation, t(11;22)(p13;q11.2), characterizes intra-abdominal desmoplastic small round-cell tumors. Cancer Genet Cytogenet 69:17–21

    Article  CAS  PubMed  Google Scholar 

  115. Ladanyi M, Gerald W (1994) Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res 54:2837–2840

    CAS  PubMed  Google Scholar 

  116. Taubert H, Wissner S, Haskins A (1965) Leiomyomatosis peritonealis disseminata: an unusual complication of genital leiomyomata. Obstet Gynecol 25:561–574

    CAS  PubMed  Google Scholar 

  117. Churg A, Cagle PT, Roggli VL (2006) Tumors of the serosal membranes. ARP, Silver Spring

    Google Scholar 

  118. Mueller F, Kuehn K, Neudeck H, Nina S, Uwe U et al (2012) Disseminated peritoneal leiomyomatosis with endometriosis. J Minim Invasive Gynecol 19(3):380–382

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors thank Prof. Frederic Bibeau for his comments and suggestions on this manuscript.

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Authors and Affiliations

  1. Department of Surgical Oncology, Zydus Hospital, Zydus hospital road, SG highway, Thaltej, Ahmedabad, 380054, India

    Aditi Bhatt

  2. Department of Pathology, Fortis Hospital, Bangalore, India

    Suniti Mishra

  3. Department of Pathology, Zydus Hospital, Ahmedabad, India

    Loma Parikh & Sandeep Sheth

  4. Department of Pathology, Aster-CMI Hospital, Bangalore, India

    Imran Gorur

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  1. Aditi Bhatt
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Correspondence to Aditi Bhatt.

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Bhatt, A., Mishra, S., Parikh, L. et al. Essentials for Pathological Evaluation of Peritoneal Surface Malignancies and Synoptic Reporting of Cytoreductive Surgery Specimens—A review and evidence-based guide. Indian J Surg Oncol 11, 101–126 (2020). https://doi.org/10.1007/s13193-019-00897-7

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