Skip to main content

Advertisement

SpringerLink
Log in

HATRICK—Synchronous Triple Primary Tumors of Thyroid

  • Case Report
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Multiple primary cancer (MPC) has an incidence of 1.8% and is defined as having two or more cancers in a single patient. Synchronous tumors are defined as ≥ 2 primary tumors occurring within 6 months of diagnosis of the first primary tumor. We present a case of a 27-year-old female patient who presented with a painless, gradually progressive right-sided neck swelling for the last 1 year with no systemic complaints. Examination revealed a 4 × 3-cm, firm, smooth surfaced swelling on right lobe of thyroid. USG neck showed a hypoechoic solid nodule on the right lobe and the left lobe was normal. FNAC showed features of adenomatous colloid nodule, Bethesda II. Right hemithyroidectomy specimen revealed evidence of triple tumors—not otherwise-specified (NOS) tumor, papillary carcinoma thyroid, and medullary carcinoma thyroid, which was confirmed with positivity on IHC with synaptophysin, CEA, and chromogranin. Concurrent appearance of NOS, PTC, and medullary carcinoma thyroid in the very same patient is extremely rare and has not been previously reported in the English literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Sipos JA, Mazzaferri EL (2010) Thyroid cancer epidemiology and prognostic variables. Clin Oncol (R Coll Radiol) 22(6):395–404. https://doi.org/10.1016/j.clon.2010.05.004

    Article  CAS  Google Scholar 

  2. Moertel CG, Dockerty MB, Baggenstoss AH (1961) Multiple primary malignant neoplasms. II. Tumor of different tissues or organs. Cancer 14:231–237. https://doi.org/10.1002/1097-0142(196103/04)14:2<231::AID-CNCR2820140203>3.0.CO;2-2

    Article  CAS  PubMed  Google Scholar 

  3. Demandante CG, Troyer DA, Miles TP (2003) Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol 26:79–83. https://doi.org/10.1097/00000421-200302000-00015

    Article  PubMed  Google Scholar 

  4. Warren S, Gates O (1932) Multiple primary maligant tumors: a survey of the literature and a statistical study. Am J Cancer 16:1358–1414

    Google Scholar 

  5. Kim WG, Gong G, Kim EY, Kim TY, Hong SJ, Kim WB, Shong YK (2010) Concurrent occur-rence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin Endocrinol 72(2):256–263. https://doi.org/10.1111/j.1365-2265.2009.03622.x

    Article  Google Scholar 

  6. Wong RL, Kazaure HS, Roman SA, Sosa JA (2012) Simultaneous medullary and dif-ferentiated thyroid carcer: a population-level analysis of an increasingly common entity. Ann Surg Oncol 19(8):2635–2642. https://doi.org/10.1245/s10434-012-2357-8

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. John’s Medical College and Hospital, Bengaluru, Karnataka, India

    A. P. Roshini

  2. Department of Surgical Oncology, St. John’s Medical College and Hospital, Bengaluru, Karnataka, India

    Rakesh Ramesh

  3. Department of Pathology, St. John’s Medical College and Hospital, Bengaluru, Karnataka, India

    T. Rajalakshmi

Authors
  1. A. P. Roshini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rakesh Ramesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Rajalakshmi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rakesh Ramesh.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roshini, A.P., Ramesh, R. & Rajalakshmi, T. HATRICK—Synchronous Triple Primary Tumors of Thyroid. Indian J Surg Oncol 9, 592–594 (2018). https://doi.org/10.1007/s13193-018-0772-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-018-0772-4

Keywords

Search

Navigation