References
Corcoran JN, Jacoby KJ, Olives TD, Bangh SA, Cole JB. Persistent hyperinsulinemia following high-dose insulin therapy: a case report. J Med Toxicol. 2020;16:465–9.
Rabkin R, Ryan MP, Duckworth WC. The renal metabolism of insulin. Diabetologia. 1984;27:351–7.
Ferrannini E, Wahren J, Faber OK, Felig P, Binder C, DeFronzo RA. Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol-Endocrinol Metab. 1983;244:E517–27.
Rabkin R, Simon NM, Steiner S, Colwell JA (2010) Effect of renal disease on renal uptake and excretion of insulin in man. N Engl J Med 1970; 282:182–187.
Katz AI, Rubenstein AH. Metabolism of proinsulin, insulin, and C-peptide in the rat. J Clin Invest. 1973;52:1113–21.
Waldhäusl WK, Bratusch-Marrain PR, Vierhapper H, Nowotny P. Insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man. Metabolism. 1983;32:478–86.
Tomasi T, Sledz D, Wales JK, Recant L. Insulin half-life in normal and diabetic subjects. Exp Biol Med. 1967;126:315–7.
Cole JB, Arens AM, Laes JR, Klein LR, Bangh SA, Olives TD. High dose insulin for beta-blocker and calcium channel-blocker poisoning. Am J Emerg Med. 2018;36:1817–24.
Fasching P, Roden M, Stühlinger HG, Kurzemann S, Zeiner A, Waldhäusl W, et al. Estimated glucose requirement following massive insulin overdose in a patient with type 1 diabetes. Diabet Med. 1994;11:323–5.
Mégarbane B, Deye N, Bloch V, Sonneville R, Collet C, Launay J-M, et al. Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles. Crit Care. 2007;11:R115.
Shibutani Y, Ogawa C. Suicidal insulin overdose in a type 1 diabetic patient: relation of serum insulin concentrations to the duration of hypoglycemia. J Diabetes Complications. 2000;14:60–2.
Holger JS, Stellpflug SJ, Cole JB, Harris CR, Engebretsen KM. High-dose insulin: a consecutive case series in toxin-induced cardiogenic shock. Clin Toxicol. 2011;49:653–8.
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Corcoran, J.N., Jacoby, K.J., Olives, T.D. et al. In Reply: “On Insulin Kinetics Following High-Dose Insulin Therapy, and When to Stop Therapy”. J. Med. Toxicol. 17, 235–236 (2021). https://doi.org/10.1007/s13181-021-00829-4
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DOI: https://doi.org/10.1007/s13181-021-00829-4