ACMT Position Statement: Alternative or Contingency Countermeasures for Acetylcholinesterase Inhibiting Agents
First responders and health care providers must prepare to provide care for patients poisoned by acetylcholinesterase (AchE) inhibitor chemical warfare agents or pesticides. However, pre-deployed medical countermeasures (MCMs) may not be sufficient due to production and delivery interruption, rapid depletion of contents during a response, expiration of MCM components, or lack of local availability of approved MCMs. To augment supplies of community-based and forward-deployed nerve agent countermeasures, the American College of Medical Toxicology (ACMT) supports several strategies: (1) The use of expired atropine, diazepam, and pralidoxime auto-injectors and vials if non-expired drugs are unavailable; and (2) Investigation, development, and identification of alternative countermeasures—commonly stocked drugs that are not approved for nerve agent poisoning but are in the same therapeutic class as approved drugs.
KeywordsAcetylcholinesterase inhibitors Atropine Pralidoxime Countermeasures Expiration date
This statement was funded, in part, by the United States Department of Homeland Security ACMT/DHS Contract number HSHQDC-14-R-00102.
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Conflicts of Interest
While individual practices may differ, this is the position of the American College of Medical Toxicology (ACMT) at the time written, after a review of the issue and pertinent literature.
- 1.United States Department of Health and Human Services. Chemical Hazards. Emergency Medical Management. https://chemm.nlm.nih.gov/chempack.htm. Accessed 19 Jan 2018.
- 5.United States Department of Health and Human Services (Food and Drug Administration). Expiration Dating Extension. https://www.fda.gov/EmergencyPreparedness/Counterterrorism/MedicalCountermeasures/MCMLegalRegulatoryandPolicyFramework/ucm411446.htm. Accessed 19 Jan 2018.
- 6.United States Department of Health and Human Services (Food and Drug Administration). Memorandum Expiry Dating Extension Update for AtroPen (atropine), CANA (diazepam), Morphine Sulfate, and Pralidoxime Chloride. Auto-Injectors. https://www.fda.gov/downloads/Drugs/DrugSafety/UCM496442.pdf. March 2, 2016. Accessed 19 Jan 2018.