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68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull

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Abstract

We report the case of a 32 year-old male with Chondroblastic Osteosarcoma of the skull, which was imaged with both 18[F]fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and 68Gallium-arginine-glycine-aspartic acid (68Ga-RGD) PET/CT. The 18F-FDG PET/CT did not demonstrate the tumour, whereas the 68Ga-RGD PET/CT clearly depicted a left-sided frontal tumour. 68Ga-RGD PET/CT may be a clinically useful imaging modality for early detection of recurrent osteosarcoma, considering the limitations of 18F-FDG PET in a setting of low glycolytic activity.

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Fig. 1
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Abbreviations

PET/CT:

Positron emission tomography/computed tomography

68Ga-RGD:

68Gallium-arginine-glycine-aspartic acid

18F-FDG:

18[F]fluorodeoxyglucose

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Acknowledgments

Ms. I Schoeman and Dr. B Mokaleng for their contributions to ensuring quality control of Ga68 radiopharmaceuticals. We thank Prof. E Raubenheimer who provided histology images on behalf of George Mukhari Academic Hospital.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa

    Akintunde Orunmuyi, Moshe Modiselle, Thabo Lengana, Thomas Ebenhan, Mariza Vorster & Mike Sathekge

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  1. Akintunde Orunmuyi
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  2. Moshe Modiselle
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  3. Thabo Lengana
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  4. Thomas Ebenhan
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  5. Mariza Vorster
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  6. Mike Sathekge
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Corresponding author

Correspondence to Mike Sathekge.

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Conflict of Interest

Akintunde Orunmuyi, Moshe Modiselle, Thabo Lengana, Thomas Ebenhan, Mariza Vorster, and Mike Sathekge, declare that they have no conflict of interest.

Ethical Statement

This study was approved by the University of Pretoria’s Research Ethics committee and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

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Orunmuyi, A., Modiselle, M., Lengana, T. et al. 68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. Nucl Med Mol Imaging 51, 271–273 (2017). https://doi.org/10.1007/s13139-016-0400-6

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  • DOI: https://doi.org/10.1007/s13139-016-0400-6

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