From diabetes to renal aging: the therapeutic potential of adiponectin

Abstract

Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunction in diabetes. Due to recent studies, adiponectin plays a key role in diabetes-related kidney diseases as a fat-derived hormone. In diabetes, reduced adiponectin levels are associated to renal cell aging. Oxidative stress and related signaling pathways are the main routes in which adiponectin may be effective to decline diabetes-associated aging. Therefore, adiponectin signaling in target tissues becomes one of the research areas of interest in metabolism and clinical medicine. Studies on adiponectin signaling will increase our understanding of adiponectin role in diabetes-linked diseases as well as shortening life span conditions which may guide the design of antidiabetic and anti-aging drugs.

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MK and MH make substantial contributions to conception and design. MK, MM, and MH participate in drafting the article or revising it critically for important intellectual content. All authors give final approval of the version to be submitted and any revised version.

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Key points

- Adiponectin improves insulin resistance through mTOR signaling

- Adiponectin improves lipotoxicity in renal cells

- Adiponectin alleviates renal cell aging

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Karamian, M., Moossavi, M. & Hemmati, M. From diabetes to renal aging: the therapeutic potential of adiponectin. J Physiol Biochem (2021). https://doi.org/10.1007/s13105-021-00790-4

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Keywords

  • Diabetes
  • Aging
  • Kidney
  • Oxidative stress
  • Adiponectin