Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent evaporation technique with different drug carrier ratio of pantoprazole: magnetite: ethyl cellulose (EC-1 = 1:1:2 and EC-2 = 1:1:4) and pantoprazole: magnetite: eudragit-RS100 (EUD-1= 1:1:2 and EUD-2 = 1:1:4). Physicochemical properties of prepared magnetic microspheres such as density of the formulated magnetic microspheres were found to be 1.32, 1.27, 1.87, and 1.53 gcm−3 for EC-1, EC-2, EUD-1, and EUD-2 respectively. Magnetic susceptibility was found to be 750, 470, 215, and 240 × 10−5 for EC-1, EC-2, EUD-1, and EUD-2. SEM proved that the formulated magnetic microspheres were smooth and spherical with the size range of 1 to 700 μm and 5 to 500 μm for ethyl cellulose and Eudragit RS-100. X-ray diffraction patterns proved that their crystalline nature of the drug in formulation was not changed. Drug release from magnetic microspheres was found to be pH dependent. The drug release from EC-1, EC-2, EUD-1, and EUD-2 was found to be 20.90%, 18.32%, 20.1%, and 13.77% w/w in pH 2; 90.71%, 78.67%, 39.03%, and 30.12% w/w in pH 7.4, and 67.61%, 57.01%, 35.16%, and 31.95% w/w in pH 8.0, respectively. Eudragit RS-100 magnetic microspheres showed controlled release of pantoprazole, when compared with ethyl cellulose formulations.
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Renata, P., Raffin, L., & Denise, S. (2006). Jornada, Maria Ines Re, Adriana R, Pohlmann and Silvia S, Guterres. Sodium pantoprazole loaded enteric microparticles prepared by spray drying. Effect of the scale of production and process validation. Int J Pharm Sci, 324, 10–18.
Vyas, S. P., & Khar, R. K. (2006). Microspheres In targeted & controlled drug delivery novel carrier systems (I ed.pp. 417–453). New Delhi: CBS publishers & Distributors.
Lacava, Z. G. M. Biological effects of magnetic fluids toxicity studies. J Magn Mag Mono, 199(201), 431–434.
Vega-Gonzalez, A., Domingo, C., Elvira, C., & Subra, P. (2004). Precipitation of PMMA/PCL blends using supercritical carbon dioxide. J Appl Polym Sci, 91, 2422–2426.
Guller, R., Hartmann, M., Rudi, J., Bliesath, H., Brod, I., Klotz, U., Huber, R., Steinijans, V. W., & Wurst, W. (1992). Lack of interaction of pantoprazole and diazepam in man. Gastroenterol, 102(suppl), A77.
Simon, B., Muller, P., Hartmann, M., Bliesath, H., Luhmann, R., Huber, R., Bohnenkamp, W., & Wurst, W. (1990b). Pentagastrin-stimulated gastric acid secretion and pharmacokinetics following single and repeated intravenous administration of the gastric H+K+ ATPase inhibitor Pantoprazole (BY1023/SK&F96022) in healthy volunteers; Z. Gastroenterol, 9, 443–447.
Report 104/92; Clinical efficacy and tolerability of 40 mg Pantoprazole once daily versus 20 mg omeprazole once daily in out-patients with Stage II or III reflux esophagitis Data on file, By Gulden K.
Huber, R., Hartmann, M., Bliesath, H., Luhmann, R., Steiunuans, V. W., & Zech, K. (1996). Pharmacokinetics of pantoprazole in man. Int J Clin Pharmacol Therap, 34, 85–194.
Bruke M, Langer R, Brem H. Central nervous system–drug delivery to treat. In Encyclopedia of Controlled Drug Delivery, Vol 1. Edited by Mathowitz E, New York. John Wiley and Sons; 1999:184-212.
Arias, J. L., Gallardo, V., Gomez-Lopera, S. A., Plaza, R. C., & Delgado, A. V. (2001). Micromachined filter-chamber array with passive valves for biochemical assays on beads. Electrophoresis, 22, 249–257.
Arias, J. L., Gallardo, V., Gomez-Lopera, S. A., Plaza, R. C., & Delgado, A. V. (2001). Synthesis and characterization of poly (ethyl-2-cyanoacrylate) nanoparticles with a magnetic core. J Control Release, 77, 309–321.
Khollam, Y. B., Dhage, S. R., & Potdar, H. S. (2006). Evaluation of ciprofloxacin–loaded Eudragit RS100 or RL100PLGA nanoparticles. Int J Pharm, 314, 72–82.
PUR-study protocol. Efficacy and safety of intravenous pantoprazole in comparison to intravenous ranitidine in patients after endoscopic haemostasis of the peptic ulcer bleeding to prevent re-bleeding. By Gulden K. Pharmaceuticals Konstanz, Germany, Nov. 11.1999.
Van Rensburg, C. J., Thrope, A., Warren, B., et al. (1997). Intragastric Ph in patients with bleeding peptic ulceration during pantoprazole infusion of 8 mg/hour. Gasroenterology, 112(4), A321.
Subbiah L, Palanisamy S, Thimiri Govinda Raj DB, Development and characterization of glucosamine sulfate magnetic nanoparticles for rheumatoid arthritis chemotherapy (2020) IET MNL 10.1049/mnl.2019.0748.
Thimiri Govinda Raj, D. B., & Khan, N. A. (2020). Venkatachalam S, Chu DT, Step by step protocol for superparamagnetic nanoparticle based plasma membrane isolation from eukaryotic cell. Methods Mol Biol, 2125, 173–179.
Thimiri Govinda Raj, D. B., Khan, N. A., Venkatachalam, S., Chu, D. T., & Arumugam, S. (2020). Step by step protocol for superparamagnetic nanoparticle based endosome and lysosome isolation from eukaryotic cell. Methods Mol Biol, 2125, 167–172.
Thimiri Govinda Raj, D. B., & Khan, N. A. (2019). Protocol for eukaryotic plasma membrane isolation using superparamagnetic nanoparticles. J Magn Magn Mater, 476, 628–631.
Thimiri Govinda Raj, D. B., & Khan, N. A. (2018). Surface functionalization dependent subcellular localization of superparamagnetic nanoparticle in plasma membrane and endosome. Nano convergence, 5(4), 29492374.
Thimiri Govinda Raj DB, Khan NA. Synthesis of hybrid gold nanoparticles functionalized superparamagnetic nanoparticles. Micro-Nano Letters 2018 13 (3):292 10.1049/mnl.2017.0574.
Thimiri Govinda Raj, D. B., & Khan, N. A. (2016). Designer nanoparticle: nano-biotechnology tool for cell biology. Nano Convergence, 3(1), 22–28191432.
This work was supported by the Anna University Tiruchirappalli, Tamil Nadu.
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Latha, S., Selvamani, P., Suganya, G. et al. Preparation and In-vitro Evaluation of Pantoprazole Sodium Magnetic Microspheres by Emulsion Solvent Evaporation Method. BioNanoSci. (2021). https://doi.org/10.1007/s12668-021-00837-2
- Magnetic microspheres
- Pantoprazole sodium
- Ethyl cellulose
- Eudragit RS-100