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Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning

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Abstract

In this study, hollow microparticles were produced with polymethylsilsesquioxane/chitosan/bovine hydroxyapatite/hexagonal boron nitride (PCBB) polyblend using single-nozzle electrospinning method. Also, hollow microparticles are loaded with amoxicillin (AMX) and their drug delivery capabilities have been studied according to a treatment of osteomyelitis disease. The morphology, chemical groups, particle size, antimicrobial activity, and AMX drug release were systematically studied using scanning electron microscopy (SEM), optical microscopy, Fourier transformation infrared spectroscopy (FTIR), hollow microparticle size measurements, antimicrobial activity test, and UV spectroscopy. In vitro biocompatibility was analyzed with human bone osteosarcoma (U2OS) cell line. This present work can help in the design of a drug delivery platform for antimicrobial effect and bone repair at the same time for osteomyelitis disease treatment.

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Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, Institute of Pure and Applied Sciences, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Esra Altun & Mehmet Onur Aydogdu

  2. Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Esra Altun, Mehmet Onur Aydogdu & Oguzhan Gunduz

  3. Department of Medical Microbiology, Medipol University, Beykoz, 34810, Istanbul, Turkey

    Fatma Koc

  4. Nanotechnology Research and Application Center, EFSUN-Center of Excellence for Functional Surfaces and Interfaces for Nano Diagnostic, Sabanci University, Tuzla, 34956, Istanbul, Turkey

    Ozlem Kutlu

  5. Molecular Biology Genetics and Bioengineering Program, Sabanci University, Tuzla, 34956, Istanbul, Turkey

    Devrim Gozuacik

  6. Department of Bioengineering, Yildiz Technical University, Esenler, 34220, İstanbul, Turkey

    Sevil Yucel

  7. Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Oguzhan Gunduz

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  1. Esra Altun
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Correspondence to Oguzhan Gunduz.

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Altun, E., Aydogdu, M.O., Koc, F. et al. Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning. BioNanoSci. 8, 790–801 (2018). https://doi.org/10.1007/s12668-018-0539-y

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