Depolymerized Chitosan Enhances the Lysis of Staphylococcus aureus Cells by Lysostaphin
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The improper use of antibiotics in the treatment of bacterial infections has resulted in the appearance of spreading resistant strains . Among them, Staphylococcus aureus has been recognized as an important pathogen both in community-acquired and healthcare-associated infections. S. aureus has successfully become resistant to practically all antibiotics, and this is a serious clinical problem in the world today . Therefore, the search for new pharmaceuticals alternative to antibiotics and design of new treatment approaches of staphylococcal infections are important tasks.
Lysostaphin is a zinc metalloenzyme which has a specific lytic action against S. aureus. Glycylglycine endopeptidase specifically cleaves the glycine–glycine bonds, unique to the interpeptide cross-bridge of the S. aureus cell wall. Due to its unique specificity, lysostaphin could have high potential in the treatment of antibiotic-resistant staphylococcal infections .
It is known that lysostaphin...
This work was supported by the grant №16-14-00046 of Russian Science Foundation (preparation and characterization of chitosans) and funded by the subsidy of the Russian Government to support the Program of Competitive Growth of Kazan Federal University among World’s Leading Academic Centers (biological experiments).
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Conflict of Interest
The authors declare that they have no conflict of interest.
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