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BioNanoScience

, Volume 8, Issue 1, pp 313–318 | Cite as

Exploring the Integration of Threaded Implants: the Chemical Deep Etching Approach

  • Fanilya A. Hafizova
  • Ruslan M. Mirgazizov
  • Rais G. Hafizov
  • Airat M. Mirgazizov
  • Dmitriy E. Tsyplakov
  • Irek R. Hafizov
  • Dina A. Azizova
  • Мikhail A. Sergeev
  • Airat R. Kayumov
  • Marsel Z. Mirgazizov
Article

Abstract

While various techniques for analyses of the bone/implant interface are developed, most of them do not show the osseointegration process in details. In this article, we present a new inverted approach to explore the osseointegration of the dental implants, based on the chemical deep etching of titanium implants. An approach was tested on 18 implants inserted in 6 dogs. Bone/implant blocks were taken after 1, 3, and 6 months after implantation. The titanium was chemically removed from the interface, leaving the bone tissue intact. Once metal was removed, bone tissue was analyzed macroscopically and with a scanning electron microscope, afterwards decalcified and used for histological analysis. The clear patterns of implant integration into the bone tissue were obtained after 1, 3, and 6 months after implantation. After 1 month, the bone/implant interface was still very immature. After 3 months, the bone was already quite mature and organized. After 6 months, the external bone layer on the bone/implant interface appeared in its final osseointegrated form. The presented inverted method for the osseointegration analysis offers new insight into the healing process of the bone/implant interface after implantation, as well as integrative processes occurring around implants with different surfaces and designs.

Keywords

Dental implants Bone tissue Histology Osseointegration 

Notes

Funding Information

We like to acknowledge the support of this work by the Russian Science Foundation (project No. 15-14-00046) and subsidy of the Russian Government to support the Program of competitive development of Kazan Federal University.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Fanilya A. Hafizova
    • 1
  • Ruslan M. Mirgazizov
    • 1
  • Rais G. Hafizov
    • 1
  • Airat M. Mirgazizov
    • 1
  • Dmitriy E. Tsyplakov
    • 2
  • Irek R. Hafizov
    • 2
  • Dina A. Azizova
    • 1
  • Мikhail A. Sergeev
    • 3
  • Airat R. Kayumov
    • 1
  • Marsel Z. Mirgazizov
    • 1
  1. 1.Kazan Federal UniversityKazanRussia
  2. 2.Kazan State Medical UniversityKazanRussia
  3. 3.Bauman Kazan State Academy of Veterinary MedicineKazanRussia

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