PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging
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In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.
KeywordsDysprosium-doped Fe3O4 Superparamagnetic nanoparticles MRI imaging Toxicity
We would like to thank Ms. Gulnoza Urmanova (Department of Biotechnology, NUUz) for cytotoxicity measurements. We would also like to thank the funding grant provided by NU to conduct the preliminary research.
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