Vitamin D levels in ulcerative colitis at first diagnosis: Does it “bell the cat”?
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Higher vitamin D levels in inflammatory bowel disease (IBD) are shown to be associated with improved quality of life , reduced rates of Clostridium difficile infection , reduced surgical rates , and lowered risk of cancers including colorectal cancer . However, the presence and impact of vitamin D deficiency in treatment-naïve ulcerative colitis (UC) patients remain unexplored. Thus, the present case-control study was undertaken to compare the blood levels of vitamin D in patients with UC at the time of the first diagnosis and those in age- and sex-matched healthy controls.
This prospective study was done at two centers: Choithram Hospital and Research Centre, Indore (MJ) and Gleneagles Global Health City, Chennai (MJ, VJ) between 2012 and 2016. We included 30 treatment-naïve patients with UC with a confirmed diagnosis at registration. The diagnosis was based on clinical, endoscopic, and histopathological confirmation; we compared their data with 60 age- and...