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Indian Journal of Gastroenterology

, Volume 37, Issue 3, pp 266–270 | Cite as

Regression of fibrosis in pediatric liver diseases

  • Vikrant SoodEmail author
  • Bikrant Bihari Lal
  • Archana Rastogi
  • Rajeev Khanna
  • Dinesh Rawat
  • Seema Alam
Case Series
  • 58 Downloads

Abstract

The concept of irreversibility of cirrhosis has been challenged in the recent past with literature in this regard, albeit still scarce, now being accumulated across all age groups, etiologies, and geographical regions. This small series of nine pediatric cases elegantly recapitulates the concept of regression of hepatic fibrosis/cirrhosis and paves way for further detailed studies to enable development of therapeutic anti-fibrotic modalities in future.

Keywords

Hepatic fibrosis Pediatric liver diseases Regression 

Notes

Compliance with ethical standards

Conflict of interest

VS, BBL, AR, RK, DR, and SA declare that they have no conflict of interest.

Ethics statement

The authors declare that the study was performed in a manner to conform with the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.

Supplementary material

12664_2018_847_MOESM1_ESM.docx (298 kb)
ESM 1 (DOCX 298 kb)

References

  1. 1.
    Popper H, Udenfriend S. Hepatic fibrosis: correlation of biologic and morphologic investigations. Am J Med. 1970;49:707–21.CrossRefPubMedGoogle Scholar
  2. 2.
    Perez-Tamayo R. Cirrhosis of the liver: a reversible disease? Pathol Ann. 1979;14:183–213.Google Scholar
  3. 3.
    Friedman SL, Bansal MB. Reversal of hepatic fibrosis: fact or fantasy. Hepatology. 2006;43:S82–8.CrossRefPubMedGoogle Scholar
  4. 4.
    Ismail MH, Pinzani M. Reversal of liver fibrosis. Saudi J Gastroenterol. 2009;15:72–9.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Goodman ZD. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol. 2007;47:598–607.CrossRefPubMedGoogle Scholar
  6. 6.
    Wanless IR, Nakashima E, Sherman M. Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med. 2000;124:1599–607.PubMedGoogle Scholar
  7. 7.
    Bortolotti F, Guido M, Cadrobbi P, et al. Spontaneous regression of hepatitis B virus associated liver cirrhosis developed in childhood. Dig Liver Dis. 2004;37:964–7.CrossRefGoogle Scholar
  8. 8.
    Bortolotti F, Guido M, Bartolacci S, et al. Chronic hepatitis B in children following e antigen seroclearance: final report of a 29-year longitudinal study. Hepatology. 2006;43:556–62.CrossRefPubMedGoogle Scholar
  9. 9.
    Pradhan AM, Bhave SA, Joshi VV, Bavdekar AR, Pandit AN, Tanner MS. Reversal of Indian childhood cirrhosis by D-penicillamine therapy. J Pediatr Gastroenterol Nutr. 1995;20:28–35.CrossRefPubMedGoogle Scholar
  10. 10.
    Ustundag G, Kuloglu Z, Kirsaçlioğlu CT, et al. Complete regression of cirrhosis after immunosuppressive treatment in autoimmune hepatitis. Pediatr Int. 2008;50:711–3.CrossRefPubMedGoogle Scholar
  11. 11.
    Borssén ÅD, Palmqvist R, Kechagias S, et al. Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis: a cohort study. Medicine (Baltimore). 2017;96:e7708.CrossRefGoogle Scholar
  12. 12.
    Arnell H, Papadogiannakis N, Zemack H, Knisely AS, Németh A, Fischler B. Follow-up in children with progressive familial intrahepatic cholestasis after partial external biliary diversion. J Pediatr Gastroenterol Nutr. 2010;51:494–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Kurbegov AC, Setchell KD, Haas JE, et al. Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile. Gastroenterology. 2003;125:1227–34.CrossRefPubMedGoogle Scholar
  14. 14.
    Bortolotti F, Guido M. Reversal of liver cirrhosis: a desirable clinical outcome and its pathogenic background. J Pediatr Gastroenterol Nutr. 2007;44:401–6.CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Gastroenterology 2018

Authors and Affiliations

  • Vikrant Sood
    • 1
    Email author
  • Bikrant Bihari Lal
    • 1
  • Archana Rastogi
    • 2
  • Rajeev Khanna
    • 1
  • Dinesh Rawat
    • 1
  • Seema Alam
    • 1
  1. 1.Department of Pediatric HepatologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  2. 2.Department of PathologyInstitute of Liver and Biliary SciencesNew DelhiIndia

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