Indian Journal of Gastroenterology

, Volume 37, Issue 2, pp 160–163 | Cite as

Absence of chronic hepatitis E virus infection in liver transplant recipients: Report from a hyperendemic region

  • Pragya Agarwala
  • Ekta Gupta
  • Manish Chandra Choudhary
  • Viniyendra Pamecha
Short Report


Most cases of chronic hepatitis E virus (HEV) infection in solid organ transplant recipients are attributable to genotype 3. Although India is hyperendemic for HEV genotype 1, chronic infection in transplant patients has not been reported. In this study, 30 liver transplant recipients were followed up by systematic testing for various markers of HEV (IgM, IgG, HEV-Ag, and RNA) on blood and stool samples obtained pre-transplant, and then at 3 and 6 months post-transplant to look for HEV exposure and persistence. Evidence of HEV infection was found in 6 (20%) cases post-transplant but none of the recipients demonstrated active viremia or antigenemia. This suggests that the circulating genotype of HEV in our population might have limited potential to cause chronic infections.


Chronic hepatitis Liver disease Viral hepatitis 



We acknowledge Mr. Nadeem Hasnain and Mr. Gaurav Singh for their help in patient recruitment and technical support respectively.

Compliance with ethical standards

Conflict of interest

PA, EG, MCC, and VP declare that they have no conflict of interest.

Ethical clearance

The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on

The study was approved by the institutional ethics committee and review board.


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Copyright information

© Indian Society of Gastroenterology 2018

Authors and Affiliations

  • Pragya Agarwala
    • 1
  • Ekta Gupta
    • 1
  • Manish Chandra Choudhary
    • 1
  • Viniyendra Pamecha
    • 2
  1. 1.Department of Clinical VirologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  2. 2.Department of HPB SurgeryInstitute of Liver and Biliary SciencesNew DelhiIndia

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