Indian Journal of Gastroenterology

, Volume 37, Issue 2, pp 86–91 | Cite as

No increased risk of perforation during colonoscopy in patients undergoing propofol versus traditional sedation: A meta-analysis

  • Minmin Xue
  • Jian Tian
  • Jing Zhang
  • Hongbin Zhu
  • Jun Bai
  • Sujuan Zhang
  • Qili Wang
  • Shuge Wang
  • Xuzheng Song
  • Donghong Ma
  • Jia Li
  • Yongmin Zhang
  • Wei Li
  • Dongxu Wang
Original Article


Background and Aims

The safety of propofol sedation during colonoscopy remains unclear, and we performed a meta-analysis to assess the risk of perforation in patients undergoing propofol vs. traditional sedation.


MEDLINE, CBM, VIP, CNKI, and Wanfang databases were searched up to December 2016. Two reviewers independently assessed abstract of those searched articles. Data about perforation condition in propofol and traditional sedation groups were extracted and combined using the random effects model.


A total of 19 studies were included in the current meta-analysis. Compared to traditional sedation, propofol sedation did not increase the risk of perforation (RD = − 0.00, 95% CI − 0.00~0.00, p = 0.98; subgroup analysis: OR = 1.30, 95% CI 0.83~2.05, p = 0.25).


This meta-analysis suggested that propofol sedation did not increase the risk of perforation compared to traditional sedation during colonoscopy.


Colonoscopy Perforation Propofol sedation Risk 


Compliance with ethical standards

Conflict of interest

MX, JT, JZ, HZ, JB, SZ, QW, SW, XS, DM, JL,YZ, WL, and DW declare that they have no conflicts of interests.

Ethics statement

There are no ethical issues involved in our study for our data were based on published studies.

Supplementary material

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Copyright information

© Indian Society of Gastroenterology 2018

Authors and Affiliations

  • Minmin Xue
    • 1
  • Jian Tian
    • 1
  • Jing Zhang
    • 1
  • Hongbin Zhu
    • 1
  • Jun Bai
    • 1
  • Sujuan Zhang
    • 1
  • Qili Wang
    • 1
  • Shuge Wang
    • 1
  • Xuzheng Song
    • 1
  • Donghong Ma
    • 1
  • Jia Li
    • 1
  • Yongmin Zhang
    • 1
  • Wei Li
    • 1
  • Dongxu Wang
    • 1
  1. 1.Department of GastroenterologyChinese People’s Liberation Army 254 HospitalTianjinPeople’s Republic of China

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