Indian Journal of Gastroenterology

, Volume 37, Issue 2, pp 79–85 | Cite as

Efficacy of narrow-band imaging in detecting early esophageal cancer and risk factors for its occurrence

  • Wei Gai
  • Xi-Feng Jin
  • Ronglian Du
  • Ling Li
  • Tong-Hai Chai
Original Article
  • 60 Downloads

Abstract

Objective

The aim of this study is to evaluate the efficacy of narrow-band imaging (NBI) in the detecting early esophageal cancer and precancerous lesions and to investigate the risk factors for its occurrence.

Methods

The esophagus was examined with ordinary endoscopy, NBI, and iodine staining. All the lesions were confirmed by histopathologically as the gold standard; NBI and intrapapillary capillary scale (IPCL) scale were compared with pathologic diagnosis. The accuracy, sensitivity, specificity, positive and negative predictive values (PPV, NPV) were calculated. Subgroup analysis was performed between the elderly vs. younger group, and head and neck squamous cell cancer (HNSCC) vs. non-HNSCC patients.

Results

Ninety lesions were detected with ordinary endoscopy, 108 with NBI, and 120 with iodine staining. All esophageal cancers were detected both by NBI and by iodine staining. Accuracy, sensitivity, and specificity for esophageal cancer and precancerous lesion were 67.8%, 58.1%, and 76.6%; 92%, 89.7%, and 96%; 93.4%, 93.4%, and 93.2%, respectively. NBI endoscopy and iodine staining were superior to ordinary endoscopy for detecting esophageal cancer and precancerous lesions (p < 0.05). NBI showed better detection of esophageal neoplasms in the elderly patients (p < 0.001). The incidence of multiple squamous cell cancers (SCCs) was significantly higher in non-elderly group (p = 0.009). NBI can also detect more esophageal neoplastic lesions in patients with head and neck cancers (p = 0.003).

Conclusions

NBI endoscopy appears as effective as Lugol staining to detect and screen the early esophageal cancer. NBI shows better detection of esophageal neoplasms in the elderly patients. The incidence of multiple SCCs was much higher in non-elderly patients.

Keywords

Endoscopy Esophageal neoplasms Narrow band imaging Precancerous lesions 

Notes

Acknowledgments

This project was supported by China Scholarship Council.

Compliance with ethical standards

Conflicts statement

WG, XFJ, RD, LL, and THC declare that they have no conflict of interest.

Ethics statement

The authors declare that the study was performed in a manner to conform with the Helsinki Declaration of 1975, as revised in 2000 and 2008, concerning Human and Animal Rights. The protocol was approved by the Institutional Ethics Committee, and informed consent was obtained from the study subjects.

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Copyright information

© Indian Society of Gastroenterology 2018

Authors and Affiliations

  • Wei Gai
    • 1
  • Xi-Feng Jin
    • 1
    • 2
  • Ronglian Du
    • 1
  • Ling Li
    • 1
  • Tong-Hai Chai
    • 1
  1. 1.Department of GastroenterologyTengzhou Central People’s HospitalTengzhouChina
  2. 2.Department of Internal MedicineUniversity-Hospital Campus Grosshadern, Ludwig-Maximilian University of MunichMunichGermany

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