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Effect of Topical Application of Pure Honey in Chemo-radiation-Induced Mucositis and Its Clinical Benefits in Improving Quality of Life in Patients of Oral Squamous Cell Carcinoma

  • Comparative Study
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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Oral cancer is a major health problem in India, and in certain parts, it represents more than 50% of all cancers. Since almost all of these patients receive chemo-radiotherapy with or without surgery for treatment, a vast majority of them also develop oral mucositis, a debilitating adverse effect of chemo-radiation. There have been various reports in the literature regarding the beneficial role of honey in the management of oral mucositis. The objective of this study was to investigate whether the application of honey in mucositis confers any significant improvement in lesions of mucositis and more specifically whether application of honey brings about any improvement in the quality of life of patients suffering from chemo-radiation-induced oral mucositis. If found to be beneficial, honey could provide a simple, elegant and cost-effective solution to a troublesome health problem, thus benefiting a large number of patients.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, India

    Debraj Howlader, Vibha Singh, Shadab Mohammad & U. S. Pal

  2. Department of Radiation Oncology, King George’s Medical University, Lucknow, India

    Seema Gupta

  3. Department of Phytochemistry, National Botanical Research Institute, Lucknow, India

    Mahesh Pal

Authors
  1. Debraj Howlader
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  2. Vibha Singh
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  3. Shadab Mohammad
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  4. Seema Gupta
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  5. U. S. Pal
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  6. Mahesh Pal
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Contributions

D.H contributed to data collection and processing, V.S helped in conception of idea and study design, S.M. revised the intellectual content, S.G. involved in study design and study parameters, U.S.P. made critical review, and M.P. participated in logistic support.

Corresponding author

Correspondence to Vibha Singh.

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Howlader, D., Singh, V., Mohammad, S. et al. Effect of Topical Application of Pure Honey in Chemo-radiation-Induced Mucositis and Its Clinical Benefits in Improving Quality of Life in Patients of Oral Squamous Cell Carcinoma. J. Maxillofac. Oral Surg. 18, 73–79 (2019). https://doi.org/10.1007/s12663-017-1077-9

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  • DOI: https://doi.org/10.1007/s12663-017-1077-9

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