Journal of Maxillofacial and Oral Surgery

, Volume 17, Issue 2, pp 142–149 | Cite as

Infection, Alveolar Osteitis, and Adverse Effects Using Metronidazole in Healthy Patients Undergoing Third Molar Surgery: A Meta-analysis

  • Mario Alberto Isiordia-Espinoza
  • Othoniel H. Aragon-Martinez
  • Ronell E. Bollogna-Molina
  • Ángel J. Alonso-Castro
Review Article



The aim of this systematic review and meta-analysis was to evaluate the risk of surgical infection, alveolar osteitis, and adverse effects using systemic metronidazole in comparison with placebo in healthy patients undergoing third molar surgery.

Materials and Methods

The eligible reports were identified from diverse science sources. Clinical trials meeting the inclusion and exclusion criteria and an acceptable Oxford Quality Score were included in this study. The evaluation of risk was done using the Risk Reduction Calculator and Review Manager 5.3., from the Cochrane Library. A significant risk reduction was assumed when the upper limit of the 95% confidence intervals was <1 and the lower limit did not cross zero (negative number) alongside a p value of <0.05 for the overall test. Data of 667 patients from five clinical trials were used for the assessment of risk.


Our analysis showed no reduction of the risk of infection or dry socket in patients receiving metronidazole compared to whom took placebo. Meanwhile, the adverse effects did not exhibit a difference between the studied groups.


The routine use of systemic metronidazole to prevent surgical site infection and/or dry socket in healthy patients undergoing third molar surgery is not recommended.


Metronidazole Third molar surgery Surgical infection Alveolar osteitis Adverse effects 


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Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2017

Authors and Affiliations

  • Mario Alberto Isiordia-Espinoza
    • 1
  • Othoniel H. Aragon-Martinez
    • 2
  • Ronell E. Bollogna-Molina
    • 3
  • Ángel J. Alonso-Castro
    • 4
  1. 1.Departamento de Investigación, Escuela de OdontologíaUniversidad Cuauhtémoc plantel San LuisSan Luis PotosíMexico
  2. 2.Departamento de Farmacología, Facultad de MedicinaUniversidad Autónoma de San Luis PotosíSan Luis PotosíMexico
  3. 3.Departamento de Investigación, Facultad de OdontologíaUniversidad de la República (UDELAR)MontevideoUruguay
  4. 4.División de Ciencias Naturales y Exactas, Departamento de FarmaciaUniversidad de GuanajuatoGuanajuatoMexico

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