Journal of Maxillofacial and Oral Surgery

, Volume 16, Issue 3, pp 322–327 | Cite as

To Compare the Efficacy of C-Reactive Protein and Total Leucocyte Count as Markers for Monitoring the Course of Odontogenic Space Infections

  • Rishi Bali
  • Parveen Sharma
  • Priya Ghanghas
  • Niti Gupta
  • Jay Dutt Tiwari
  • Abhiroop Singh
  • Nitin Sapra
  • Disha Goyal
Research Paper



To compare the efficacy of CRP and TLC as markers for monitoring the course of odontogenic space infections (OSI) in 50 patients.


A Clinical severity scale (CSS) was developed to grade the severity of infections in patients. Blood samples were taken preoperatively and postoperatively at day 1, day 2, day 3 and day 7 for measuring the levels of CRP and TLC. The trends of CRP and TLC were analysed against the CSS. The data was subjected to paired “t” test, ANOVA, Spearman rank correlation, Pearson’s bivariate correlation as appropriate.


The CRP values were elevated in all 50/50 (100 %) patients as compared to TLC which were elevated in 32/50 (64 %) patients only. The CSS displayed a high internal consistency and reliability (Cronbach α = 0.748). A significant strong positive correlation (ρ = 0.754) was found between CRP and CSS as compared to a moderate correlation (ρ = .607) between TLC and CSS.


CRP displayed a more consistent relation with clinical severity of the infection than TLC. Hence it could be more reliably employed to judge the progress in a patient with OSI.


Odontogenic space Infection CRP TLC Laboratory markers 



I thanks Mr. Varun Arora, Bio-statistician for his assistance with the statistical analysis of my research study.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Statement

Obtained for experimentation with human subjects from patients as well as from ethical committee.(F/Ethical/1593). The study design was approved by the Board of Studies of the University.

Informed Consent

An informed consent was obtained from all the patients.


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Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2016

Authors and Affiliations

  • Rishi Bali
    • 1
  • Parveen Sharma
    • 1
  • Priya Ghanghas
    • 1
  • Niti Gupta
    • 1
  • Jay Dutt Tiwari
    • 1
  • Abhiroop Singh
    • 1
  • Nitin Sapra
    • 1
  • Disha Goyal
    • 1
  1. 1.Department of Oral and Maxillofacial SurgeryD.A.V (C) Dental College and HospitalYamunanagarIndia

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