Journal of Maxillofacial and Oral Surgery

, Volume 16, Issue 3, pp 377–381 | Cite as

Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region

  • Pushkar Devidas Gawande
  • Kiran Khande
  • Gaurav Agrawal
  • Amita Aditya
Case Report


Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with poor prognosis. It has an aggressive clinical course with extensive local destruction. It occurs primarily in the mandible. It may clinically present as a cystic lesion with benign clinical feature or as a large mass with ulceration, significant bone resorption and mobility of teeth in the affected region. Reliable evidence of it’s biological activity along with extensive local destruction, direct extension of tumor, lymph node involvement and metastasis to various sites (frequently lung) have been reported. Wide local excision is the treatment of choice along with regional lymph node dissection. Because of recurrence close periodic assessment of the patient is advocated. The authors discussed a rare case of AC of mandible; with metastasis to regional lymph nodes in a 45 year old male along with a long-term follow up.


Ameloblastoma Ameloblastic carcinoma Odontogenic tumour 


Compliance with Ethical Standards

Conflict of interest

Pushkar D. Gawande, Kiran Khande, Gaurav Agrawal and Amita Aditya declare that they have no conflict of interest.

Ethical Approval

Approval of the institutional ethical committee was taken.

Informed Consent

Informed consent was obtained from the patient.


  1. 1.
    Hall JM, Weather DR, Unni KK et al (2007) Ameloblastic carcinoma: an analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:799–807CrossRefPubMedGoogle Scholar
  2. 2.
    Perera E, Lindquist C, Hughes C, Thomas S (2013) The use of gamma knife stereotactic radiotherapy in the treatment of ameloblastic carcinoma. Int J Oral Maxillofac Surg 42:934–938CrossRefPubMedGoogle Scholar
  3. 3.
    Yoshioka Y, Toratani S, Ogawa I, Okamato T (2013) Ameloblastic carcinoma, secondary type, of mandible: a case report. J Oral Maxillofac Surg 71:e58–e62CrossRefPubMedGoogle Scholar
  4. 4.
    Slootweg PJ, Muller H (1984) Malignant ameloblastoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 57:168–176CrossRefGoogle Scholar
  5. 5.
    Cox DP, Muller S, Carlson GW et al (2000) Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy—associated hypercalcemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:716–722CrossRefPubMedGoogle Scholar
  6. 6.
    Karakida K, Aoki T, Sakamoto H et al (2010) Ameloblastic carcinoma secondary type: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:e33–e37CrossRefPubMedGoogle Scholar
  7. 7.
    Akrish S, Buchner A, Shoshani Y, Vered M et al (2007) Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma. J Oral Maxillofac Surg 65:777–783CrossRefPubMedGoogle Scholar
  8. 8.
    Yoon HJ, Hong SP, Lee JI, Lee SS, Hong SD (2009) Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:904–913CrossRefPubMedGoogle Scholar
  9. 9.
    Lucca M, D’Innocenzo R, Karus JA, Gagari E et al (2010) Ameloblastic carcinoma of the maxilla: a report of 2 cases. J Oral Maxillofac Surg 68:2564–2569CrossRefPubMedGoogle Scholar
  10. 10.
    Corio LR, Goldblatt LI, Edward PA, Hartman KS (1987) Ameloblastc carcinoma: a clinicopathologic study and assessment of eight cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 64:570–576CrossRefGoogle Scholar
  11. 11.
    Avon S, McComb J, Clokie C (2003) Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 69:573–576PubMedGoogle Scholar
  12. 12.
    Marx RE, Stern D (2003) Oral and maxillofacial pathology. A rationale for diagnosis and treatment. Quintessence Publishings Co, Inc, IllinoisGoogle Scholar
  13. 13.
    Mohammed S, Ram H, Husain N, Gupta P (2010) Ameloblasic carcinoma. J Maxillofac Oral Surg 9(4):415–419CrossRefGoogle Scholar

Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2016

Authors and Affiliations

  • Pushkar Devidas Gawande
    • 1
  • Kiran Khande
    • 2
  • Gaurav Agrawal
    • 3
  • Amita Aditya
    • 4
  1. 1.Department of Oral and Maxillofacial SurgerySinhgad Dental College and HospitalPuneIndia
  2. 2.Department of Oral and Maxillofacial SurgerySai Sansthan Superspeciality HospitalDist. AhmednagarIndia
  3. 3.Department of Oral and Maxillofacial PathologyS.M.B.T. Dental College and HospitalDist. AhmednagarIndia
  4. 4.Department of Oral Diagnosis and RadiologySinhgad Dental College and HospitalPuneIndia

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