Journal of Maxillofacial and Oral Surgery

, Volume 16, Issue 3, pp 277–283 | Cite as

Is the Mandibular Growth Affected by Internal Rigid Fixation?: A Systematic Review

  • Humberto Fernández-Olarte
  • Andrés Gómez-Delgado
  • Dayan López-Dávila
  • Rodolfo Rangel-Perdomo
  • Gloria Inés Lafaurie
  • Leandro Chambrone
Review Paper



The purpose of this systematic review was to evaluate, in animal model-based studies, whether there are mandibular growth alterations, after open reduction and internal rigid fixation with titanium plates and screws.


A literature search was conducted using the MEDLINE, EMBASE, and LILACS databases, up to and including August 2015. Surgical reduction and internal rigid fixation (IRF) of induced fractures were compared to non-invasive procedures, in order to investigate if there were alterations in the mandibular growth patterns.


Of a total of 624 potentially relevant papers identified through the searching process, five were eligible for inclusion. Three studies using 3-month old New Zealand white rabbits induced fractures of mandibular body or symphysis and internal fixation with titanium microplates and screws, whereas two were based on 6-month old goats with condylar fracture. None of the studies showed statistically significant difference between experimental and control groups.


As literature regarding this subject is scarce, and the included studies show low level of evidence, it is not possible to conclude that open reduction and internal rigid fixation with titanium plates and screws cause significant growing alteration of the mandible.


Open reduction Internal fixation Mandibular growth Animal model 



We want to thank Sabrina Castillo for her support and collaboration during the preparation of this article.


This study wasn´t funded by any person, institution or company.

Compliance with Ethical Standards

Ethical Approval Statement

This article contains just one study with animals performed by one of the authors. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed on it. This article does not contain any other studies with animals performed by any of the authors.

Conflict of interest

Authors Humberto Fernández Olarte, Andrés Gómez-Delgado, Dayán López-Dávila, Rodolfo Rangel-Perdomo, Gloria Inés Lafaurie, Leandro Chambrone declares that they have no conflict of interest.


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Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2016

Authors and Affiliations

  1. 1.Oral and Maxillofacial Surgery Residency ProgramUniversidad El BosqueBogotáColombia
  2. 2.Department of Oral and Maxillofacial SurgeryClínica El Bosque and Hospital Simón BolívarBogotáColombia
  3. 3.Universidad El BosqueBogotáColombia
  4. 4.Private PracticeSan JoséCosta Rica
  5. 5.Department of Oral and Maxillofacial SurgeryUniversidad El BosqueBogotáColombia
  6. 6.Unit of Basic Oral Investigations (UIBO), School of DentistryUniversidad El BosqueBogotáColombia
  7. 7.Department of Periodontics, School of DentistryUniversidad El BosqueBogotáColombia
  8. 8.Department of Periodontics, College of DentistyThe University of IowaIowa CityUSA
  9. 9.Departamento de Cirugía Oral y MaxilofacialUniversidad El BosqueBogotáColombia

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