Human Toxocariasis in individuals with blood disorders and cancer patients: the first seroepidemiological study in Iran

Abstract

Toxocara is one of the most prevalent nematodes in Iran, which infect humans as an intermediate host. Infection complications result from the larva migration. Human toxocariasis prevalence was various in Iran according to the area of study and population. This study was designed to evaluate the seropositivity of Toxocara IgG in patients with blood disorders and cancer patients in southwest Iran. Moreover, the study of the associated risk factors for this infection. A total of 1122 serum samples, from February 8, 2019 to August 21, 2019, including 600 healthy individuals and 522 individuals with cancer and blood disorders patients were collected. Serum samples were collected for detection of Toxocara IgG by using ELISA (Enzyme-Linked Immunosorbent Assay) kit. Sociodemographic data of all participants were collected and examined to determine their association with the infection. Out of 101 individuals with white blood cell disorders (5.94%), red blood cell disorders (7.48%) and cancer patients (11.06%) were seropositive for Toxocara IgG antibodies. The infection rate among all study population revealed that (10.76%) were positive for Toxocara IgG. This study showed the fundamental role of contact with pets and infection in groups with blood cell disorders (P-value ≤ 0.05%); while in cancer patients the association wasn’t significant. Other factors such as age, location of residence, and sex showed that the association with this infection wasn't significant.

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Acknowledgments

The authors express their appreciation and appreciation to all those who have contributed to this project.

Funding

None.

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Authors

Contributions

Concept and design: VR, AI, NS, FB, SE acquisition of data: PJ, MFK, AA, ZH; analysis and interpretation: MS, GA, OR, MEG.

Corresponding author

Correspondence to Asmaa Ibrahim.

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The authors and co-authors declare that they have no conflict of interest that affects this study.

Ethical statement

This study was approved ethically by the Ethics Committees at Shahid Baghaei Hospital in Ahvaz province, Iran. Before collecting blood samples, all individuals approved the informed consent form, and then blood samples were taken based on the guidelines of the Ethics Committees at Shahid Baghaei Hospital in Ahvaz province, Iran.

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Raissi, V., Sohrabi, N., Bayat, F. et al. Human Toxocariasis in individuals with blood disorders and cancer patients: the first seroepidemiological study in Iran. J Parasit Dis (2021). https://doi.org/10.1007/s12639-021-01347-4

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Keywords

  • Seroprevalence
  • Human toxocariasis
  • Blood disorders
  • Cancer patients
  • Iran