Preparation and Characterization of Acetic Acid-Functionalized Fe3O4@SiO2 Nanoparticles as an Efficient Nanocatalyst for the Synthesis of Nitrones in Water


Magnetic materials grafted with acetic acid (Fe3O4@SiO2COOH MNPs) were successfully prepared from the incorporation of bromoacetic acid as a functional group on the surface of magnetite silica nanoparticles. The catalyst has been characterized by Fourier transform infrared spectroscopy, X-ray diffraction, elemental analysis, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, scanning electron microscopy and transition electron microscopy. Next, the efficiency of this acid catalyst was examined for the synthesis of the nitrones from diaminoglyoxime in the water at room temperature. The present approach provides several advantages such as environmentally benign, excellent yields, straightforward, short reaction times, good recyclability of catalyst, cost-effective and facile catalyst separation for the preparation of nitrones compounds as an important privileged medicinal scaffold.

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The authors would like to thank Tabriz Branch, Islamic Azad University for the financial support of this research, which is based on a research project contract.

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Correspondence to Gholam Hossein Shahverdizadeh.

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Shendy, S.A., Shahverdizadeh, G.H., Babazadeh, M. et al. Preparation and Characterization of Acetic Acid-Functionalized Fe3O4@SiO2 Nanoparticles as an Efficient Nanocatalyst for the Synthesis of Nitrones in Water. Silicon 12, 1735–1742 (2020).

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  • Nanocatalyst
  • Fe3O4@SiO2COOH
  • Nitrones
  • Diaminoglyoxim
  • Condensation