Impact of ENIGMA trials on nitrous oxide: a survey of Canadian anesthesiologists and residents

  • Davinder Jain
  • Heung Kan Ma
  • Norman Buckley


Conflict of interest

None declared.

Editorial responsibility

This submission was handled by Dr. Gregory L. Bryson, Deputy Editor-in-Chief, Canadian Journal of Anesthesia.



Supplementary material

12630_2018_1060_MOESM1_ESM.pdf (45 kb)
Supplementary material 1 (PDF 44 kb)


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    Myles PS, Leslie K, Chan MT, et al. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology 2007; 107: 221-31.CrossRefPubMedGoogle Scholar
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    Myles PS, Leslie K, Chan MT, et al. The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. Lancet 2014; 384: 1446-54.CrossRefPubMedGoogle Scholar
  3. 3.
    Myles PS, Chan MT, Kasza J, et al. Severe nausea and vomiting in the evaluation of nitrous oxide in the gas mixture for anesthesia II trial. Anesthesiology 2016; 124: 1032-40.CrossRefPubMedGoogle Scholar
  4. 4.
    Sulbaek Andersen MP, Nielsen OJ, Wallington TJ, Karpichev B, Sander SP. Assessing the impact on global climate from general anesthetic gases. Anesth Analg 2012; 114: 1081-5.CrossRefPubMedGoogle Scholar

Copyright information

© Canadian Anesthesiologists' Society 2018

Authors and Affiliations

  1. 1.Department of AnesthesiaMcMaster UniversityHamiltonCanada

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